Reactome | INTS6 [nucleoplasm]

INTS6 [nucleoplasm]

Stable Identifier

R-CFA-6807440

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

INTS6, A0A8I3PDG2

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - RNA polymerase II transcribes snRNA genes (Canis familiaris)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS6 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS6 [nucleoplasm] (Canis familiaris)
    - Integrator complex processes the 3' end of snRNA (Canis familiaris)
      - Integrator [nucleoplasm] (Canis familiaris)
        
        INTS6 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS6 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS6 [nucleoplasm] (Canis familiaris)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS6 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS6 [nucleoplasm] (Canis familiaris)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Canis familiaris)
      - Integrator [nucleoplasm] (Canis familiaris)
        
        INTS6 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS6 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PDG2

Gene Names

INTS6

Reference Genes

ENSEMBL:ENSCAFG00845021506.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845021506.1 INTS6

Other Identifiers

476905

Cfa.1009.1.A1_at

Cfa.19987.1.S1_at

GO:0005634

GO:0005654

GO:0005856

GO:0015629

GO:0016073

GO:0016180

GO:0032039

GO:0043226

Participates

as a component of

Integrator [nucleoplasm] (Canis familiaris)

Inferred From

INTS6 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000102786

Ensembl

ENSCAFT00845037976, ENSCAFG00845021506, ENSCAFP00845029759