Reactome | Ints6 [nucleoplasm]

Ints6 [nucleoplasm]

Stable Identifier

R-RNO-6807440

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

INTS6, A0A8I6AP01

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - RNA polymerase II transcribes snRNA genes (Rattus norvegicus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints6 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints6 [nucleoplasm] (Rattus norvegicus)
    - Integrator complex processes the 3' end of snRNA (Rattus norvegicus)
      - Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints6 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints6 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints6 [nucleoplasm] (Rattus norvegicus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints6 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints6 [nucleoplasm] (Rattus norvegicus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Rattus norvegicus)
      - Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints6 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints6 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A8I6AP01

Gene Names

Ints6

Reference Genes

BioGPS Gene:361057 Ints6

ENSEMBL:ENSRNOG00000009873

KEGG:rno:361057 Ints6

Monarch:361057 Ints6

NCBI Gene:361057 Ints6

UCSC:A0A8I6AP01 Ints6

Reference Transcript

Other Identifiers

10784416

1378384_at

1399123_at

17703670

361057

5701043

5711259

5754888

5789129

5791971

5914754

5924121

5943286

5955121

6008125

6030918

6038521

6053785

6098652

6131087

6161750

6264397

6292591

6294445

6329945

6358141

6418461

6520329

6530957

6638774

6641153

6652106

6726078

6738553

A_44_P151981

A_44_P555082

GO:0000785

GO:0005634

GO:0005654

GO:0005856

GO:0006351

GO:0006366

GO:0006368

GO:0015629

GO:0016073

GO:0016180

GO:0030674

GO:0032039

GO:0060090

GO:0071168

GO:0160232

GO:0160240

PH_rn_0020614

rc_AA924369_at

Participates

as a component of

Integrator [nucleoplasm] (Rattus norvegicus)

Inferred From

INTS6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_038949439.1, XP_063130496.1, XP_063130493.1, XP_063130497.1, XP_063130494.1, XP_063130492.1, NP_001258417.1, XP_063130495.1

ENSEMBL

ENSRNOG00000009873, ENSRNOT00000101257, ENSRNOP00000095908

RGD

1309480