Reactome | IntS6 [nucleoplasm]

IntS6 [nucleoplasm]

Stable Identifier

R-DME-6807440

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

INTS6, Q9W485

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - RNA polymerase II transcribes snRNA genes (Drosophila melanogaster)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS6 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS6 [nucleoplasm] (Drosophila melanogaster)
    - Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)
      - Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS6 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS6 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS6 [nucleoplasm] (Drosophila melanogaster)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS6 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS6 [nucleoplasm] (Drosophila melanogaster)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Drosophila melanogaster)
      - Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS6 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS6 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W485

Gene Names

IntS6

Reference Genes

BioGPS Gene:31496 IntS6

ENSEMBL:FBgn0261383

Flybase:FBgn0261383

KEGG Gene (Drosophila melanogaster):Dmel_CG3125 IntS6

Monarch:31496 IntS6

NCBI Gene:31496 IntS6

UCSC:Q9W485 IntS6

Reference Transcript

Other Identifiers

142995_at

144546_at

1628824_s_at

31496

GO:0003674

GO:0005634

GO:0016073

GO:0016180

GO:0032039

GO:0034472

GO:0043226

Participates

as a component of

Integrator [nucleoplasm] (Drosophila melanogaster)

Inferred From

INTS6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001259261.1, NP_001259260.1, NP_727026.1, NP_572253.2, NP_001259259.1

Flybase

FBgn0261383

PRO

Q9W485