Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing
|J. Cell Biol.
90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors
Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis
|Nucleic Acids Res.