Reactome | LCN2 [extracellular region]

LCN2 [extracellular region]

Stable Identifier

R-HSA-5215934

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Neutrophil gelatinase-associated lipocalin, NGAL_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P80188 LCN2

Gene Names

LCN2, HNL, NGAL

Chain

signal peptide:1-20, chain:21-198

Reference Genes

BioGPS Gene:3934 LCN2

COSMIC - genes:LCN2 LCN2

CTD Gene:3934 LCN2

dbSNP Gene:3934 LCN2

ENSEMBL:ENSG00000148346 LCN2

HGNC:6526 LCN2

KEGG:hsa:3934 LCN2

Monarch:3934 LCN2

NCBI Gene:3934 LCN2

OMIM:600181 LCN2

UCSC:P80188 LCN2

Reference Transcript

Other Identifiers

11757634_a_at

17089525

212531_PM_at

212531_at

3190192

3190193

3190194

3190195

3190196

3190198

3190199

3190200

3190201

3190202

3190204

3190205

3190208

3190209

32821_at

3934

8158167

A_14_P100877

A_23_P169437

GE81528

GE88852

GO:0002020

GO:0002376

GO:0005506

GO:0005515

GO:0005576

GO:0005615

GO:0006811

GO:0006826

GO:0006915

GO:0006953

GO:0006954

GO:0006979

GO:0007614

GO:0007616

GO:0009410

GO:0009615

GO:0009617

GO:0009635

GO:0009636

GO:0009637

GO:0009750

GO:0010040

GO:0010046

GO:0010595

GO:0010628

GO:0015891

GO:0031346

GO:0031410

GO:0031667

GO:0031669

GO:0032496

GO:0035580

GO:0036094

GO:0036295

GO:0042742

GO:0042802

GO:0043065

GO:0043525

GO:0045087

GO:0050877

GO:0060205

GO:0070062

GO:0070301

GO:0071222

GO:0071347

GO:0071354

GO:0071356

GO:0071456

GO:0071481

GO:0097192

GO:0098542

GO:0110090

GO:0110091

GO:0120162

GO:0140315

GO:1903428

GO:1903981

GO:1904373

GO:1904440

GO:1904646

GO:1905956

GO:1990090

GO:2000379

HMNXSV003047065

Hs.204238.0.S1_3p_at

ILMN_1692223

PH_hs_0011986

S75256_s_at

TC09000677.hg

X99133_at

Participates

as a member of

as a component of

LCN2:2,5DHBA [extracellular region] (Homo sapiens)

Other forms of this molecule

LCN2 [specific granule lumen]

Inferred To

ptgds [extracellular region] (Xenopus tropicalis)

Dmel\CG44014 [extracellular region] (Drosophila melanogaster)

LCN2 [extracellular region] (Bos taurus)

LCN2 [extracellular region] (Canis familiaris)

LCN2 [extracellular region] (Danio rerio)

LCN2 [extracellular region] (Mus musculus)

LCN2 [extracellular region] (Rattus norvegicus)

LCN2 [extracellular region] (Sus scrofa)

Homologues of LCN2 [extracellular region] (Danio rerio)

ptgdsb.2 [extracellular region] (Danio rerio)

ptgdsa [extracellular region] (Danio rerio)

PTGDS [extracellular region] (Gallus gallus)

ptgdsb.1 [extracellular region] (Danio rerio)

lcn15 [extracellular region] (Danio rerio)

Cross References

RefSeq

XP_047279332.1, NP_005555.2, XP_054218938.1

OpenTargets

ENSG00000148346

ENSEMBL

ENST00000277480, ENSG00000148346, ENST00000373017, ENSP00000362108, ENSP00000277480

HPA

ENSG00000148346-LCN2

GeneCards

LCN2

PRO

P80188

Pharos - Targets

P80188

PDB

3HWD, 4ZHH, 3CBC, 4ZHG, 5N47, 4ZHD, 8UYN, 1X8U, 4GH7, 3PEC, 8UZ9, 9JDO, 1L6M, 6QMU, 6Z6Z, 1DFV, 4K19, 5KIC, 3TZS, 3TF6, 3FW5, 3FW4, 5NKN, 3DSZ, 3CMP, 1NGL, 6S8V, 1X71, 3I0A, 4IAW, 3HWG, 6Z2C, 5KHP, 3HWE, 4MVI, 4QAE, 5MHH, 3DTQ, 3BY0, 6SUA, 4ZHF, 5N48, 3PED, 4ZHC, 6O5D, 3T1D, 5KID, 3K3L, 4ZFX, 5JR8, 3U0D, 1QQS, 1X89, 4IAX, 6GR0, 4MVK, 3HWF, 4MVL, 6GQZ

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.666	4
UniProt:O43715 TRIAP1	1	TRIAP1 [mitochondrial intermembrane space] (R-HSA-1307778)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902)	0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:Q9Y6Y9 LY96	3	LY96 [extracellular region] (R-HSA-9707658) LY96 [endosome membrane] (R-HSA-2201307) 2xN4GlycoAsn-LY96 [plasma membrane] (R-HSA-166047)	0.556	3
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	3
UniProt:Q969M7 UBE2F	3	UBE2F [cytosol] (R-HSA-947635) AcM-UBE2F [cytosol] (R-HSA-8951623) G76-NEDD8-C116-AcM-UBE2F [cytosol] (R-HSA-8951758)	0.556	3
UniProt:Q9H0D6 XRN2	2	XRN2 [nucleoplasm] (R-HSA-6791205) XRN2 [cytosol] (R-HSA-391297)	0.556	3
UniProt:Q96FA3 PELI1	2	p-PELI1 [cytosol] (R-HSA-450815) PELI1 [cytosol] (R-HSA-450696)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:Q99816 TSG101	2	TSG101 [endosome membrane] (R-HSA-2980549) TSG101 [cytosol] (R-HSA-917727)	0.556	3
UniProt:Q969H8 MYDGF	1	C19orf10 [endoplasmic reticulum lumen] (R-HSA-535584)	0.556	3
UniProt:Q969S2 NEIL2	1	NEIL2 [nucleoplasm] (R-HSA-5649650)	0.556	3
UniProt:Q6ISS4 LAIR2	1	LAIR2 [extracellular region] (R-HSA-5696342)	0.556	3
UniProt:O14595 CTDSP2	1	CTDSP2 [nucleoplasm] (R-HSA-535488)	0.556	3
UniProt:P54646 PRKAA2	5	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) p-T172-PRKAA2 [endoplasmic reticulum lumen] (R-HSA-9931258) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3

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