Reactome | LCN2 [specific granule lumen]

LCN2 [specific granule lumen]

Stable Identifier

R-HSA-6799614

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule lumen

Synonyms

Neutrophil gelatinase-associated lipocalin, NGAL_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P80188 LCN2

Gene Names

LCN2, HNL, NGAL

Chain

signal peptide:1-20, chain:21-198

Reference Genes

BioGPS Gene:3934 LCN2

COSMIC (genes):LCN2 LCN2

CTD Gene:3934 LCN2

dbSNP Gene:3934 LCN2

ENSEMBL:ENSG00000148346 LCN2

HGNC:6526 LCN2

KEGG:hsa:3934 LCN2

Monarch:3934 LCN2

NCBI Gene:3934 LCN2

OMIM:600181 LCN2

UCSC:P80188 LCN2

Reference Transcript

RefSeq:NM_005564.4 LCN2

Other Identifiers

11757634_a_at

17089525

212531_PM_at

212531_at

3190192

3190193

3190194

3190195

3190196

3190198

3190199

3190200

3190201

3190202

3190204

3190205

3190208

3190209

32821_at

3934

8158167

A_14_P100877

A_23_P169437

GE81528

GE88852

GO:0002376

GO:0005506

GO:0005515

GO:0005576

GO:0005615

GO:0006826

GO:0006915

GO:0012501

GO:0015891

GO:0031410

GO:0035580

GO:0036094

GO:0042742

GO:0042802

GO:0043226

GO:0045087

GO:0060205

GO:0070062

GO:0098542

GO:0120162

GO:0140313

GO:0140315

GO:1903981

HMNXSV003047065

Hs.204238.0.S1_3p_at

ILMN_1692223

PH_hs_0011986

S75256_s_at

TC09000677.hg

X99133_at

Participates

as a member of

Specific granule lumen proteins [specific granule lumen] (Homo sapiens)

Other forms of this molecule

LCN2 [extracellular region]

Inferred To

ptgdsa [specific granule lumen] (Danio rerio)

ptgds [specific granule lumen] (Xenopus tropicalis)

Homologues of LCN2 [specific granule lumen] (Danio rerio)

Dmel\CG44014 [specific granule lumen] (Drosophila melanogaster)

lcn15 [specific granule lumen] (Danio rerio)

ptgdsb.2 [specific granule lumen] (Danio rerio)

ptgdsb.1 [specific granule lumen] (Danio rerio)

LCN2 [specific granule lumen] (Bos taurus)

LCN2 [specific granule lumen] (Canis familiaris)

LCN2 [specific granule lumen] (Danio rerio)

LCN2 [specific granule lumen] (Gallus gallus)

LCN2 [specific granule lumen] (Mus musculus)

LCN2 [specific granule lumen] (Rattus norvegicus)

LCN2 [specific granule lumen] (Sus scrofa)

Cross References

RefSeq

NP_005555.2

OpenTargets

ENSG00000148346

ENSEMBL

ENSP00000362108, ENST00000277480, ENST00000373017, ENSP00000277480

HPA

ENSG00000148346-LCN2

PRO

P80188

Pharos - Targets

P80188

PDB

4ZHH, 4ZHG, 4ZHD, 1X8U, 3PEC, 4MVI, 3CMP, 5KHP, 3HWF, 4IAW, 3HWD, 6S8V, 6Z2C, 6GR0, 3TF6, 3FW5, 4ZFX, 6QMU, 5JR8, 6O5D, 1NGL, 1X71, 3U0D, 3I0A, 5KID, 1L6M, 4K19, 1DFV, 5N48, 3BY0, 3CBC, 4ZHF, 6SUA, 5NKN, 3PED, 4ZHC, 4MVK, 3HWG, 4IAX, 3HWE, 6GQZ, 4QAE, 5MHH, 3DTQ, 3K3L, 3FW4, 6Z6Z, 1QQS, 1X89, 3DSZ, 4MVL, 5KIC, 4GH7, 5N47, 3T1D, 3TZS

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.666	4
UniProt:Q969S2 NEIL2	1	NEIL2 [nucleoplasm] (R-HSA-5649650)	0.556	3
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.556	3
UniProt:Q9Y6Y9 LY96	3	LY96 [extracellular region] (R-HSA-9707658) LY96 [endosome membrane] (R-HSA-2201307) 2xN4GlycoAsn-LY96 [plasma membrane] (R-HSA-166047)	0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:Q9H0D6 XRN2	2	XRN2 [nucleoplasm] (R-HSA-6791205) XRN2 [cytosol] (R-HSA-391297)	0.556	3
UniProt:Q969H8 C19orf10	1	C19orf10 [endoplasmic reticulum lumen] (R-HSA-535584)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q969M7 UBE2F	3	UBE2F [cytosol] (R-HSA-947635) AcM-UBE2F [cytosol] (R-HSA-8951623) G76-NEDD8-C116-AcM-UBE2F [cytosol] (R-HSA-8951758)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:O14595 CTDSP2	1	CTDSP2 [nucleoplasm] (R-HSA-535488)	0.556	3
UniProt:Q6ISS4 LAIR2	1	LAIR2 [extracellular region] (R-HSA-5696342)	0.556	3
UniProt:O43715 TRIAP1	1	TRIAP1 [mitochondrial intermembrane space] (R-HSA-1307778)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	3

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