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NDUFA8 [mitochondrial inner membrane]
Stable Identifier
R-HSA-60627
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH-ubiquinone oxidoreductase 19 kDa subunit , Complex I-19KD, CI-19KD, Complex I-PGIV, CI-PGIV
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFA8 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51970 NDUFA8
Gene Names
NDUFA8
Chain
initiator methionine:, chain:2-172
Reference Genes
BioGPS Gene:4702 NDUFA8
COSMIC (genes):NDUFA8 NDUFA8
CTD Gene:4702 NDUFA8
dbSNP Gene:4702 NDUFA8
ENSEMBL:ENSG00000119421 NDUFA8
HGNC:7692 NDUFA8
KEGG:hsa:4702 NDUFA8
Monarch:4702 NDUFA8
NCBI Gene:4702 NDUFA8
OMIM:603359 NDUFA8
UCSC:P51970 NDUFA8
Reference Transcript
RefSeq:NM_014222.2 NDUFA8
Other Identifiers
11716205_a_at
17098071
218160_PM_at
218160_at
3224198
3224199
3224200
3224203
3224205
3224208
3224209
43795_s_at
4702
8163930
GO:0003824
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0005758
GO:0006091
GO:0006120
GO:0008137
GO:0009060
GO:0016491
GO:0032981
GO:0042776
GO:0043226
GO:0044877
GO:0045271
GO:0055085
GO:0055086
GO:0065003
GO:1901135
GO:1902600
HMNXSV003027189
ILMN_1759729
PH_hs_0002682
PH_hs_0031138
TC09001554.hg
g7657368_3p_at
Participates
as a component of
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
Inferred To
ND-19 [mitochondrial inner membrane]
(Drosophila melanogaster)
Ndufa8 [mitochondrial inner membrane]
(Mus musculus)
Ndufa8 [mitochondrial inner membrane]
(Rattus norvegicus)
NDUFA8 [mitochondrial inner membrane]
(Bos taurus)
NDUFA8 [mitochondrial inner membrane]
(Canis familiaris)
NDUFA8 [mitochondrial inner membrane]
(Gallus gallus)
NDUFA8 [mitochondrial inner membrane]
(Sus scrofa)
ndua-8 [mitochondrial inner membrane]
(Caenorhabditis elegans)
ndufa8 [mitochondrial inner membrane]
(Danio rerio)
ndufa8 [mitochondrial inner membrane]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000373768
,
ENSP00000362873
,
ENSG00000119421
OpenTargets
ENSG00000119421
GeneCards
NDUFA8
HPA
ENSG00000119421-NDUFA8
PRO
P51970
Pharos - Targets
P51970
GlyGen
P51970
HMDB Protein
HMDBP00130
PDB
5XTI
,
5XTH
,
5XTD
,
5XTC
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.564
5
UniProt:O43181 NDUFS4
1
NDUFS4 [mitochondrial inner membrane]
(R-HSA-163946)
0.527
2
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.527
2
UniProt:P03886 MT-ND1
1
MT-ND1 [mitochondrial inner membrane]
(R-HSA-60551)
0.527
2
UniProt:P03905 MT-ND4
1
MT-ND4 [mitochondrial inner membrane]
(R-HSA-60561)
0.527
2
UniProt:O95139 NDUFB6
1
NDUFB6 [mitochondrial inner membrane]
(R-HSA-59938)
0.527
2
UniProt:Q9UI09 NDUFA12
1
NDUFA12 [mitochondrial inner membrane]
(R-HSA-59864)
0.527
2
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
3
UniProt:P03915 MT-ND5
1
MT-ND5 [mitochondrial inner membrane]
(R-HSA-60565)
0.527
2
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.527
2
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