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NDUFS4 [mitochondrial inner membrane]
Stable Identifier
R-HSA-163946
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH-ubiquinone oxidoreductase 18 kDa subunit
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
NDUF subunits bind to form the FP subcomplex (Homo sapiens)
FP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFS4 [mitochondrial inner membrane] (Homo sapiens)
NDUFS4 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
FP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFS4 [mitochondrial inner membrane] (Homo sapiens)
FP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFS4 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
FP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFS4 [mitochondrial inner membrane] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
FP subcomplex (-NDUFAF2) [mitochondrial inner membrane] (Homo sapiens)
NDUFS4 [mitochondrial inner membrane] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
FP subcomplex (-NDUFAF2) [mitochondrial inner membrane] (Homo sapiens)
NDUFS4 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43181 NDUFS4
Gene Names
NDUFS4
Chain
transit peptide:1-42, chain:43-175
Reference Genes
BioGPS Gene:4724 NDUFS4
COSMIC (genes):NDUFS4 NDUFS4
CTD Gene:4724 NDUFS4
dbSNP Gene:4724 NDUFS4
ENSEMBL:ENSG00000164258 NDUFS4
HGNC:7711 NDUFS4
KEGG:hsa:4724 NDUFS4
Monarch:4724 NDUFS4
NCBI Gene:4724 NDUFS4
OMIM:602694 NDUFS4
UCSC:O43181 NDUFS4
Reference Transcript
RefSeq:NM_002495.3 NDUFS4
Other Identifiers
11716340_a_at
16984741
209303_PM_at
209303_at
2809425
2809429
2809432
2809433
2809437
2809442
2809443
2809451
2809452
2809453
2809454
38695_at
45509_g_at
4724
8105311
A_23_P257198
GE61878
GO:0001932
GO:0003824
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0006091
GO:0006120
GO:0007420
GO:0008137
GO:0009060
GO:0016491
GO:0022900
GO:0032981
GO:0042776
GO:0043226
GO:0045271
GO:0048856
GO:0051591
GO:0055085
GO:0055086
GO:0065003
GO:0072593
GO:1901135
GO:1902600
HMNXSV003026523
ILMN_1812312
PH_hs_0001068
TC05000221.hg
g13528959_3p_at
Participates
as an input of
NDUF subunits bind to form the FP subcomplex (Homo sapiens)
as a component of
FP subcomplex [mitochondrial inner membrane] (Homo sapiens)
FP subcomplex (-NDUFAF2) [mitochondrial inner membrane] (Homo sapiens)
Inferred To
ndufs4 [mitochondrial inner membrane]
(Danio rerio)
ndufs4 [mitochondrial inner membrane]
(Xenopus tropicalis)
ND-18 [mitochondrial inner membrane]
(Drosophila melanogaster)
lpd-5 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Ndufs4 [mitochondrial inner membrane]
(Mus musculus)
Ndufs4 [mitochondrial inner membrane]
(Rattus norvegicus)
NDUFS4 [mitochondrial inner membrane]
(Bos taurus)
NDUFS4 [mitochondrial inner membrane]
(Canis familiaris)
NDUFS4 [mitochondrial inner membrane]
(Gallus gallus)
NDUFS4 [mitochondrial inner membrane]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000296684
,
ENSP00000296684
OpenTargets
ENSG00000164258
HPA
ENSG00000164258-NDUFS4
PRO
O43181
Pharos - Targets
O43181
GlyGen
O43181
Orphanet
NDUFS4
HMDB Protein
HMDBP00137
PDB
5XTB
,
5XTH
,
5XTI
,
5XTD
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.725
7
UniProt:Q9P0J0 NDUFA13
8
NDUFA13 [mitochondrial inner membrane]
(R-HSA-59936)
NDUFA13(41-49) [mitochondrial inner membrane]
(R-HSA-9839958)
NDUFA13(100-108) [mitochondrial inner membrane]
(R-HSA-9839959)
NDUFA13(109-144) [mitochondrial inner membrane]
(R-HSA-9839968)
NDUFA13(2-19) [mitochondrial inner membrane]
(R-HSA-9839966)
NDUFA13(69-99) [mitochondrial inner membrane]
(R-HSA-9839964)
NDUFA13(20-40) [mitochondrial inner membrane]
(R-HSA-9839963)
NDUFA13(50-68) [mitochondrial inner membrane]
(R-HSA-9839961)
0.643
4
UniProt:O43678 NDUFA2
1
NDUFA2 [mitochondrial inner membrane]
(R-HSA-60178)
0.564
3
UniProt:O95182 NDUFA7
1
NDUFA7 [mitochondrial inner membrane]
(R-HSA-59858)
0.527
3
UniProt:O95292 VAPB
2
VAPB [Golgi membrane]
(R-HSA-9715115)
VAPB [endoplasmic reticulum membrane]
(R-HSA-429718)
0.527
2
UniProt:O75251 NDUFS7
1
NDUFS7 [mitochondrial matrix]
(R-HSA-6788521)
0.527
3
UniProt:P56181 NDUFV3
1
NDUFV3 [mitochondrial inner membrane]
(R-HSA-163943)
0.527
4
UniProt:Q8WTR4 GDPD5
1
GDPD5 [endoplasmic reticulum membrane]
(R-HSA-6814136)
0.527
2
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
4
UniProt:P19526 FUT1
1
FUT1 [Golgi membrane]
(R-HSA-9034059)
0.527
3
UniProt:O95169 NDUFB8
4
NDUFB8(1-186) [mitochondrial intermembrane space]
(R-HSA-8986140)
NDUFB8(1-186) [mitochondrial inner membrane]
(R-HSA-8986184)
NDUFB8(1-28) [mitochondrial matrix]
(R-HSA-8986166)
NDUFB8 [mitochondrial inner membrane]
(R-HSA-163938)
0.527
2
UniProt:Q8NCL4 GALNT6
1
GALNT6 [Golgi membrane]
(R-HSA-913608)
0.527
2
UniProt:P27930 IL1R2
1
IL1R2 [plasma membrane]
(R-HSA-197598)
0.527
3
UniProt:Q9UI09 NDUFA12
1
NDUFA12 [mitochondrial inner membrane]
(R-HSA-59864)
0.527
3
UniProt:Q9GZM5 YIPF3
0.527
2
UniProt:P51970 NDUFA8
1
NDUFA8 [mitochondrial inner membrane]
(R-HSA-60627)
0.527
2
UniProt:O43920 NDUFS5
1
NDUFS5 [mitochondrial inner membrane]
(R-HSA-60226)
0.527
3
UniProt:Q16795 NDUFA9
1
NDUFA9 [mitochondrial matrix]
(R-HSA-163942)
0.527
4
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.527
2
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