Reactome | NDUFA8 [mitochondrial inner membrane]

NDUFA8 [mitochondrial inner membrane]

Stable Identifier

R-DRE-60627

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

mitochondrial inner membrane

Synonyms

Q6PC22

Locations in the PathwayBrowser

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Metabolism (Danio rerio)

- The citric acid (TCA) cycle and respiratory electron transport (Danio rerio)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Danio rerio)
    - Respiratory electron transport (Danio rerio)
      - Complex I biogenesis (Danio rerio)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Danio rerio)
        
        315kDa subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Danio rerio)
        
        550kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        315kDa subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        815kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        550kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        315kDa subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Danio rerio)
        
        815kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        550kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        315kDa subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        980kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        815kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        550kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        315kDa subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Danio rerio)
        
        315kDa subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        550kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        315kDa subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Danio rerio)
        
        980kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        815kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        550kDa complex [mitochondrial inner membrane] (Danio rerio)
        
        315kDa subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
        
        Complex I [mitochondrial inner membrane] (Danio rerio)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Danio rerio)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Danio rerio)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Danio rerio)
        
        Complex I [mitochondrial inner membrane] (Danio rerio)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Danio rerio)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Danio rerio)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Danio rerio)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Danio rerio)
        
        HP subcomplex [mitochondrial inner membrane] (Danio rerio)
        
        NDUFA8 [mitochondrial inner membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PC22

Reference Genes

BioGPS Gene:393700

dbSNP Gene:393700

ENSEMBL:ENSDARG00000058041

KEGG Gene (Danio rerio):393700

Monarch:393700

NCBI Gene:393700

Reference Transcript

RefSeq:NM_200727.1

Other Identifiers

393700

A_15_P106018

A_15_P516987

AAH59501

BC059501

BX571668

Dr.14986.1.S1_at

ENSDARG00000058041

ENSDARP00000075289

ENSDART00000080843

EntrezGene:393700

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0008150

GO:0016020

GO:0032991

GO:0034641

GO:0043226

GO:0044281

GO:0055114

GO:0070469

IPR016680

ndufa8

ndufa8-201

NM_200727

NP_957021

UPI00001D6E2E

ZDB-GENE-040426-1688

Participant Of

hasComponent

HP subcomplex [mitochondrial inner membrane]

Inferred From

NDUFA8 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_957021.1