Reactome | Ndufa8 [mitochondrial inner membrane]

Ndufa8 [mitochondrial inner membrane]

Stable Identifier

R-RNO-60627

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

mitochondrial inner membrane

Synonyms

NDUFA8, F7EXQ7

Locations in the PathwayBrowser

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Metabolism (Rattus norvegicus)

- The citric acid (TCA) cycle and respiratory electron transport (Rattus norvegicus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Rattus norvegicus)
    - Respiratory electron transport (Rattus norvegicus)
      - Complex I biogenesis (Rattus norvegicus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        980kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Rattus norvegicus)
        
        980kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
        
        Complex I [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Rattus norvegicus)
        
        Complex I [mitochondrial inner membrane] (Rattus norvegicus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Rattus norvegicus)
        
        HP subcomplex [mitochondrial inner membrane] (Rattus norvegicus)
        
        Ndufa8 [mitochondrial inner membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:F7EXQ7

Gene Names

Ndufa8

Reference Genes

ENSEMBL:ENSRNOG00000005668

ENSEMBL:ENSRNOG00000005668 Ndufa8

Other Identifiers

10844726

1371355_at

17771703

296658

5897451

6195194

6267574

6293572

6710064

A_44_P423528

GE12603

GO:0003674

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005747

GO:0005758

GO:0006091

GO:0006120

GO:0007005

GO:0008150

GO:0022607

GO:0032981

GO:0032991

GO:0043226

GO:0044877

GO:0055114

GO:0065003

GO:0070469

ILMN_1371540

PH_rn_0007824

rc_AI232012_at

Participant Of

hasComponent

HP subcomplex [mitochondrial inner membrane]

Inferred From

NDUFA8 [mitochondrial inner membrane] (Homo sapiens)

Cross References

Ensembl

ENSRNOP00000050148, ENSRNOT00000044885, ENSRNOG00000005668

RGD

1306283

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