Reactome | NDUFA8 [mitochondrial inner membrane]

NDUFA8

Stable Identifier

R-BTA-60627

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

mitochondrial inner membrane

Synonyms

P42029

Locations in the PathwayBrowser

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Metabolism (Bos taurus)

- The citric acid (TCA) cycle and respiratory electron transport (Bos taurus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Bos taurus)
    - Respiratory electron transport (Bos taurus)
      - Complex I biogenesis (Bos taurus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA8 [mitochondrial inner membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:P42029

Reference Genes

BioGPS Gene:327710

dbSNP Gene:327710

ENSEMBL:ENSBTAG00000004295

KEGG Gene (Bos taurus):bta:327710

Monarch:327710

NCBI Gene:327710

Reference Transcript

RefSeq:NM_175826.4

Other Identifiers

327710

5LC5

5LDW

5LDX

AAI05366

BC105365

Bt.59.1.S1_at

CAA42218

ENSBTAG00000004295

ENSBTAP00000005628

ENSBTAT00000005628

EntrezGene:327710

GO:0003674

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005743

GO:0005747

GO:0005758

GO:0006091

GO:0006120

GO:0006461

GO:0007005

GO:0008150

GO:0016020

GO:0022607

GO:0032981

GO:0034641

GO:0043226

GO:0043234

GO:0044281

GO:0044877

GO:0055114

GO:0065003

GO:0070469

IPR010625

IPR016680

NDUFA8

NM_175826

NP_787020

PF06747

UPI0000167F47

X59697

Participant Of

hasComponent

HP subcomplex [mitochondrial inner membrane]

Inferred From

NDUFA8 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_787020.1

PDB

5LDX, 5LC5, 5LDW, 5O31