Reactome | MT-ND5 [mitochondrial inner membrane]

MT-ND5 [mitochondrial inner membrane]

Stable Identifier

R-HSA-60565

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3)

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External Reference Information

External Reference

UniProt:P03915 MT-ND5

Gene Names

MT-ND5, MTND5, NADH5, ND5

Chain

chain:1-603

Reference Genes

BioGPS Gene:4540 MT-ND5

COSMIC (genes):MT-ND5 MT-ND5

CTD Gene:4540 MT-ND5

dbSNP Gene:4540 MT-ND5

ENSEMBL:ENSG00000198786 MT-ND5

ENSEMBL_homo_sapiens_GENE:ENSG00000198786.2 MT-ND5

HGNC:7461 MT-ND5

KEGG Gene (Homo sapiens):4540 MT-ND5

Monarch:4540 MT-ND5

NCBI Gene:4540 MT-ND5

OMIM:516005 MT-ND5

Reference Transcript

RefSeq:NC_012920.1 MT-ND5

Other Identifiers

11762525_s_at

1555653_PM_at

1555653_at

17100675

17100677

17100679

17100681

17100683

17119762

17126272

17126278

211600_PM_at

211600_at

4037664

4037666

4037668

4037670

4037671

4037672

4037673

4037674

4037676

4037678

4037680

4037682

4037684

4540

8165680

8165682

8165684

8165686

8165690

A_23_P406928

GO:0001666

GO:0003824

GO:0003954

GO:0005215

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0009060

GO:0010243

GO:0015990

GO:0016020

GO:0016491

GO:0032981

GO:0042542

GO:0042773

GO:0042776

GO:0043226

GO:0055085

GO:0055086

GO:0065003

GO:0070469

GO:1901135

HMNXSV003005389

Hs2Affx.1.415.S1_3p_at

RNA143452|tRNA_369_71

RNA143502|tRNA_419_69

TC08001295.hg

TC0M000008.hg

TC0M000009.hg

TC0M000010.hg

TC0M000024.hg

g885925_3p_at

Participates

as a member of

Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)

as an input of

ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)

as a component of

Inferred To

nduo-5 [mitochondrial inner membrane] (Caenorhabditis elegans)

Ghost homologue of MT-ND5 [mitochondrial inner membrane] (Canis familiaris)

ND5 [mitochondrial inner membrane] (Bos taurus)

Mt-nd5 [mitochondrial inner membrane] (Rattus norvegicus)

Mtnd5 [mitochondrial inner membrane] (Mus musculus)

mt-nd5 [mitochondrial inner membrane] (Danio rerio)

mt-nd5 [mitochondrial inner membrane] (Xenopus tropicalis)

MT-ND5 [mitochondrial inner membrane] (Gallus gallus)

MT-ND5 [mitochondrial inner membrane] (Sus scrofa)

mt:ND5 [mitochondrial inner membrane] (Drosophila melanogaster)

Cross References

RefSeq

YP_003024036.1

OpenTargets

ENSG00000198786

IntEnz

7.1.1.2

HPA

ENSG00000198786-MT-ND5

GeneCards

P03915

Ensembl

ENSP00000354813, ENST00000361567, ENSG00000198786

PRO

P03915

Pharos - Targets

P03915

Orphanet

16483

HMDB Protein

HMDBP00139

PDB

5XTD, 5XTC, 5XTI, 5XTH

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.643	3
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	2
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.527	4
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.527	2
UniProt:P19526 FUT1	1	FUT1 [Golgi membrane] (R-HSA-9034059)	0.527	2
UniProt:P25103 TACR1	2	TACR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869122) TACR1 [plasma membrane] (R-HSA-380103)	0.527	2
UniProt:Q9GZM5 YIPF3			0.527	4
UniProt:O43674 NDUFB5	1	NDUFB5 [mitochondrial inner membrane] (R-HSA-163944)	0.527	3
UniProt:P51970 NDUFA8	1	NDUFA8 [mitochondrial inner membrane] (R-HSA-60627)	0.527	2
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.527	3
UniProt:Q9H6D8 FNDC4			0.527	2
UniProt:Q16795 NDUFA9	1	NDUFA9 [mitochondrial matrix] (R-HSA-163942)	0.527	3
UniProt:Q6UWR7 ENPP6	1	ENPP6 [plasma membrane] (R-HSA-6814799)	0.527	2
UniProt:Q9UI09 NDUFA12	1	NDUFA12 [mitochondrial inner membrane] (R-HSA-59864)	0.527	2

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