Reactome | p-S857 NCOA3 binds ETV4

p-S857 NCOA3 binds ETV4

Stable Identifier

R-HSA-5687097

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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NCOA3 interacts with ETV4 (also known as PEA3) in a manner that depends on S857 phosphorylation (Long et al, 2012). ETV4 and NCOA3 coactivate expression of a number of MMP genes, which play roles in cell motility and invasiveness in a subset of lung carcinomas (Long et al, 2012; Qin et al, 2008; Yan et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
18593949	Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression Erdem, H, Tsai, SY, Yan, J, Li, R, Tsai, MJ, Ittmann, M, Ayala, G, Cai, Y, Yu-Lee, LY	Cancer Res.	2008
22505454	ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion O'Malley, BW, Foulds, CE, Tsai, SY, Liu, J, Long, W, Tsai, MJ, Wistuba, II, Lonard, DM, Ding, C, Qin, J, Qin, J, Solis, LM	J. Clin. Invest.	2012
18644862	The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression O'Malley, BW, Redmond, A, Yuan, Y, Chen, H, Qin, L, Xu, J, Young, L, Liao, L	Mol. Cell. Biol.	2008