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TNFs bind their physiological receptors
Stable Identifier
R-HSA-5669034
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
TNFs bind their physiological receptors (Homo sapiens)
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Members of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity. These members are implicated in various acquired or genetic human diseases, ranging from septic shock to autoimmune disorders, allograft rejection and cancer (So et al. 2006).
Literature References
PubMed ID
Title
Journal
Year
16443545
Tumor necrosis factor/tumor necrosis factor receptor family members that positively regulate immunity
Lee, SW
,
So, T
,
Croft, M
Int. J. Hematol.
2006
Participants
Events
CD70 binds CD27
(Homo sapiens)
EDA binds EDAR
(Homo sapiens)
EDA:EDAR binds EDARADD
(Homo sapiens)
EDA-3 binds EDA2R
(Homo sapiens)
TNFSF11 binds TNFRSF11A, B
(Homo sapiens)
LTA trimer binds TNFRSF1A,1B,14
(Homo sapiens)
TNFRSF6B binds TNFSF6,14,15
(Homo sapiens)
TNFSF18 binds TNFRSF18
(Homo sapiens)
sBAFF,sAPRIL binds TACI,BCMA
(Homo sapiens)
OX40L binds OX40
(Homo sapiens)
TNFSF15 binds TNFRSF25
(Homo sapiens)
TNFSF8 binds TNFRSF8
(Homo sapiens)
TNFSF9 binds TNFRSF9
(Homo sapiens)
Participates
as an event of
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
Orthologous Events
TNFs bind their physiological receptors (Bos taurus)
TNFs bind their physiological receptors (Canis familiaris)
TNFs bind their physiological receptors (Danio rerio)
TNFs bind their physiological receptors (Gallus gallus)
TNFs bind their physiological receptors (Mus musculus)
TNFs bind their physiological receptors (Rattus norvegicus)
TNFs bind their physiological receptors (Sus scrofa)
TNFs bind their physiological receptors (Xenopus tropicalis)
Authored
Jassal, B (2015-01-30)
Reviewed
Rajput, A (2015-05-12)
Virgen-Slane, R (2015-05-12)
Ware, CF (2015-05-12)
Created
Jassal, B (2015-01-30)
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