Reactome | TNFSF9 binds TNFRSF9

TNFSF9 binds TNFRSF9

Stable Identifier

R-HSA-8858475

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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TNFRSF9 (Tumor necrosis factor receptor superfamily member 9/4-1BB/CD137) is induced when T cells receive antigen-specific stimuli. Its ligand is TNFSF9 (Tumor necrosis factor ligand superfamily member 9/ 4-1BBL/CD137L) and is induced on antigen-presenting cells, such as dendritic cells, macrophages, and B cells. TNFSF9 forms homotrimers like rest of the TNF ligands and it may interact with three TNFRSF9 receptors. Structure of TNFSF9/TNFRSF9 is not available but model has been proposed where one receptor interacts predominantly with just one ligand from the trimer and only slightly with the C-terminal tail of the adjacent subunit (Won et al. 2009). TNFRSF9/TNFSF9 pathway co-stimulates T cells to carry out effector functions such as eradication of established tumors (Halstead et al. 2002, Bertram et al. 2002) and the broadening of primary and memory CD8+ T cell responses (Won et al. 2010, Vinay et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
20032458	The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily Rice, AJ, Won, EY, Byun, JS, Kwon, BS, Ahn, B, Cha, K, Shin, S, Walz, T, Kim, YH, Kim, DU, Cho, HS	J. Biol. Chem.	2010