Reactome | sBAFF,sAPRIL binds TACI,BCMA

sBAFF,sAPRIL binds TACI,BCMA

Stable Identifier

R-HSA-5676607

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

Synonyms

sTNFSF13B,sTNFSF13 binds TNFRSF13B,TNFRSF17

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

B cell activating factor (BAFF also known as TNFSF13B) and a proliferation inducing ligand (APRIL also known as TNFSF13) are two related members of the tumour necrosis factor ligand super family (TNFSF) that promote B-cell proliferation. BAFF binds to three receptors B-cell activating factor belonging to the TNF family receptor (BAFFR also known as TNFRSF13C ), B-cell maturation antigen (BCMA also known as TNFRSF17) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI also known as TNFRSF13B), whereas APRIL interacts with TACI and BCMA. BAFF and APRIL exhibit structural similarity and overlapping yet distinct receptor binding specificity. Both BAFF and APRIL bind BCMA, but the APRIL:BCMA interaction is of higher affinity. TACI binds to both BAFF and APRIL with similar affinity (Day et al. 2005, Marsters et al. 2000, Gross et al. 2000, Rickert et al. 2011). BAFF or APRIL binding to BCMA or TACI promotes B cell development, proliferation, activation, and survival (Moore et al. 1999, Schneider et al. 1999). BAFF and APRIL are secreted as trimers, but BAFF trimers can be ordered into 60-mer arrays (Liu et al. 2003, Lopez-Fraga et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
10359578	BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth Schneider, P, MacKay, F, Steiner, V, Hofmann, K, Bodmer, JL, Holler, N, Ambrose, C, Lawton, P, Bixler, S, Acha-Orbea, H, Valmori, D, Romero, P, Werner-Favre, C, Zubler, RH, Browning, JL, Tschopp, J	J. Exp. Med.	1999
10398604	BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator Moore, PA, Belvedere, O, Orr, A, Pieri, K, LaFleur, DW, Feng, P, Soppet, D, Charters, M, Gentz, R, Parmelee, D, Li, Y, Galperina, O, Giri, J, Roschke, V, Nardelli, B, Carrell, J, Sosnovtseva, S, Greenfield, W, Ruben, SM, Olsen, HS, Fikes, J, Hilbert, DM	Science	1999
11571266	Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase López-Fraga, M, Fernandez, R, Albar, JP, Hahne, M	EMBO Rep.	2001