TNFSF15 binds TNFRSF25

Stable Identifier
Reaction [binding]
Homo sapiens
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TNFRSF25 (also referred as DR3/TRAMP/LARD/WSL1) is a death-domain-containing tumor necrosis factor (TNF)-family receptor primarily expressed on T cells. It binds with TNFSF15 (TL1A), the TNF family ligand and induces T cell costimulation (Meylan et al. 2008).

Literature References
PubMed ID Title Journal Year
11911831 TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator

Olsen, HS, Moore, PA, Cho, YH, Perry, JW, Liu, D, Gentz, R, Hu, B, Kanakaraj, P, Zhou, JX, Zhang, J, Pukac, L, Feng, P, Ullrich, S, Hong, JS, Boyd, E, Ni, J, Hu, G, Wei, P, Zhuang, L, Ruben, SM, Migone, TS, Carrell, J, Kim, S, Luo, X, Chen, SF, Chen, C

Immunity 2002
18571443 The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases

Acharya, K, Keane-Myers, A, Bundoc, V, Wang, EC, Meylan, F, Kinder, M, Kahle, E, Jankovic, D, Shevach, EM, Siegel, RM, Hodges, M, Davidson, TS

Immunity 2008
Orthologous Events
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