Reactome | TNFSF18 binds TNFRSF18

TNFSF18 binds TNFRSF18

Stable Identifier

R-HSA-5675947

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is a cytokine that regulates T-cell receptor-mediated cell death and promotes leukocyte adhesion to endothelial cells. It binds to tumor necrosis factor receptor superfamily member 18 (TNFRSF18 aka GITR) (Gurney et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10074428	Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR Mark, DT, Brush, AD, Heldens, AD, Godowski, PJ, Dowd, AD, Gurney, AL, Wood, WI, Huang, RM, Baldwin, DT, Marsters, SA, Goddard, AD, Baker, KP, Gray, AM, Ashkenazi, A, Pitti, RM, Schow, AD	Curr. Biol.	1999