Reactome | EDA-3 binds EDA2R

EDA-3 binds EDA2R

Stable Identifier

R-HSA-5669013

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Ectodysplasin-A (EDA) is a trimeric type II membrane protein whose sequence includes an interrupted collagenous domain of 19 Gly-X-Y repeats and a motif conserved in the tumor necrosis factor (TNF)-related ligand family. EDA regulates ectodermal appendage formation by colocalising with cytoskeletal structures on cell surfaces (Ezer et al. 1999). Activation of the NF-kappaB pathway by the tumor necrosis factor receptor superfamily member EDAR (EDAR) and its downstream adaptator EDAR-associated death domain (EDARADD) is essential for the development of hair follicles, teeth, exocrine glands and other ectodermal structures. EDA isoform 3 specifically binds tumor necrosis factor receptor superfamily member 27 (EDA2R aka XEDAR) whilst EDA isoform 1 specifcally binds EDAR (Hymowitz et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
10484778	Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells Bayés, M, Elomaa, O, Kere, J, Ezer, S, Schlessinger, D	Hum. Mol. Genet.	1999
14656435	The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity Yan, M, Hymowitz, SG, Compaan, DM, Wallweber, HJ, de Vos, AM, Starovasnik, MA, Dixit, VM	Structure	2003