Reactome | EDA:EDAR binds EDARADD

EDA:EDAR binds EDARADD

Stable Identifier

R-HSA-5675656

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Ectodysplasin-A (EDA) is a trimeric type II membrane protein related to the tumor necrosis factor (TNF)-related ligand family. Activation of the NF-kappaB pathway by the tumor necrosis factor receptor superfamily member EDAR (EDAR) and its downstream adaptator EDAR-associated death domain (EDARADD) is essential for the development and regulation of hair follicles, teeth, exocrine glands and other ectodermal structures (Yan et al. 2002). EDA isoform 1 specifically binds EDAR. A small number of hypohidrotic ectodermal dysplasias (HEDs) are caused by mutations in EDARADD (Chassaing et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20222921	Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases Chassaing, N, Cluzeau, C, Bal, E, Guigue, P, Vincent, MC, Viot, G, Ginisty, D, Munnich, A, Smahi, A, Calvas, P	Br. J. Dermatol.	2010
11882293	Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice Yan, M, Zhang, Z, Brady, JR, Schilbach, S, Fairbrother, WJ, Dixit, VM	Curr. Biol.	2002