Reactome | CD70 binds CD27

CD70 binds CD27

Stable Identifier

R-HSA-5669024

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The CD70 antigen (CD70) is a cytokine that is found on the surface of activated but not resting T and B lymphocytes (Bowman et al. 1994). CD70 can bind to the CD27 antigen receptor (CD27), a dimeric membrane glycoprotein belonging to the tumor necrosis factor receptor family and found on the surface of most T lymphocytes (Camerini et al. 1991). This complex is thought to influence T-, B- and NK-cell functions (Salzer et al. 2013). Defects in CD27 can cause lymphoproliferative syndrome 2 (LPFS2), an autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction (van Montfrans et al. 2012, Salzer et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
22801960	Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27 Boztug, K, Bienemann, K, Daschkey, S, Ginzel, S, Borkhardt, A, Fritsch, G, Salzer, E, Seidel, MG, Santos-Valente, E, Haas, OA, Schwendinger, M, Choo, S, Gombert, M, Förster-Waldl, E, Pickl, WF	Haematologica	2013
22197273	CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia Betts, MR, Hoepelman, AI, van de Corput, L, van Montfrans, JM, Orange, JS, Otto, S, Bloem, AC, Sanders, EA, Monaco-Shawver, L, de Weger, RA, Jol-van der Zijde, CM, van Gijn, M, Tesselaar, K, Banerjee, PP	J. Allergy Clin. Immunol.	2012
1655907	The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family Walz, G, Seed, B, Borst, J, Loenen, WA, Camerini, D	J. Immunol.	1991
8120384	The cloning of CD70 and its identification as the ligand for CD27 Kelleher, K, Yetz-Aldape, J, Kriz, R, Herrmann, S, Crimmins, MA, Bowman, MR	J. Immunol.	1994