Trafficking of myristoylated proteins to the cilium

Stable Identifier
R-HSA-5624138
Type
Pathway
Species
Homo sapiens
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A number of myristoylated proteins have been shown to traffic to the cilium in a myristoyl- and UNC119B:ARL3:RP2-dependent fashion. These include the ciliary proteins Nephrocystin 3 (NPHP3) and Cystin 1 (CYS1) (Wright et al, 2011; reviewed in Schwarz et al, 2012). Myristoyl-binding by the ARL3 effector UNC119B is required in an unknown fashion for the transport of the myristoylated cargo to the cilium. At the cilium, a GTPase cycle involving the ARF-like small GTPase ARL3 and its GAP protein RP2 promote the release of the myristoylated proteins into the ciliary membrane and the recycling and ciliary exit of UNC119B (Wright et al, 2011; reviewed in Schwarz et al, 2012). ARL3 plays additional roles in the cilium coordinating the association of IFT A and IFT B complexes with the kinesin motors (Li et al, 2010; reviewed in Li et al, 2012).

Literature References
PubMed ID Title Journal Year
22085962 An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

Wright, KJ, Baye, LM, Olivier-Mason, A, Mukhopadhyay, S, Sang, L, Kwong, M, Wang, W, Pretorius, PR, Sheffield, VC, Sengupta, P, Slusarski, DC, Jackson, PK

Genes Dev. 2011
22389062 The emerging role of Arf/Arl small GTPases in cilia and ciliopathies

Li, Y, Ling, K, Hu, J

J. Cell. Biochem. 2012
20530210 The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

Li, Y, Wei, Q, Zhang, Y, Ling, K, Hu, J

J. Cell Biol. 2010
22884633 Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins

Schwarz, N, Hardcastle, AJ, Cheetham, ME

Vision Res. 2012
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