Reactome | Myristoylated NPHP3 translocates into the ciliary membrane

Myristoylated NPHP3 translocates into the ciliary membrane

Stable Identifier

R-HSA-5624130

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cilium

ReviewStatus

5/5

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Myristoylated NPHP3 translocates into the ciliary membrane

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Binding of ARL3 to UNC119B induces a conformational change that obstructs UNC119B cargo-binding and promotes the release of the myristoylated cargo into the ciliary membrane (Wright et al, 2011; Ismail et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22960633	Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119 Ismail, SA, Chen, YX, Miertzschke, M, Vetter, IR, Koerner, C, Wittinghofer, A	EMBO J.	2012
22085962	An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium Wright, KJ, Baye, LM, Olivier-Mason, A, Mukhopadhyay, S, Sang, L, Kwong, M, Wang, W, Pretorius, PR, Sheffield, VC, Sengupta, P, Slusarski, DC, Jackson, PK	Genes Dev.	2011