Myristoylated NPHP3 translocates into the ciliary membrane

Stable Identifier
R-HSA-5624130
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Binding of ARL3 to UNC119B induces a conformational change that obstructs UNC119B cargo-binding and promotes the release of the myrisoylated cargo into the ciliary membrane (Wright et al, 2011; Ismail et al, 2012).

Literature References
PubMed ID Title Journal Year
22085962 An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

Wright, KJ, Baye, LM, Olivier-Mason, A, Mukhopadhyay, S, Sang, L, Kwong, M, Wang, W, Pretorius, PR, Sheffield, VC, Sengupta, P, Slusarski, DC, Jackson, PK

Genes Dev. 2011
22960633 Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119

Ismail, SA, Chen, YX, Miertzschke, M, Vetter, IR, Koerner, C, Wittinghofer, A

EMBO J. 2012
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