Reactome | Myristoylated NPHP3 translocates into the ciliary membrane

Myristoylated NPHP3 translocates into the ciliary membrane

Stable Identifier

R-HSA-5624130

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cilium

ReviewStatus

5/5

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Myristoylated NPHP3 translocates into the ciliary membrane

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Binding of ARL3 to UNC119B induces a conformational change that obstructs UNC119B cargo-binding and promotes the release of the myrisoylated cargo into the ciliary membrane (Wright et al, 2011; Ismail et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22960633	Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119 Miertzschke, M, Wittinghofer, A, Chen, YX, Ismail, SA, Vetter, IR, Koerner, C	EMBO J.	2012
22085962	An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium Sengupta, P, Kwong, M, Baye, LM, Sang, L, Sheffield, VC, Wright, KJ, Slusarski, DC, Jackson, PK, Pretorius, PR, Wang, W, Mukhopadhyay, S, Olivier-Mason, A	Genes Dev.	2011