Reactome | ARL3:GTP binds the UNC119B complex

ARL3:GTP binds the UNC119B complex

Stable Identifier

R-HSA-5624133

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cilium

ReviewStatus

5/5

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ARL3 is an ARF-like small GTPase that is localized to the cilium in both the GDP- and the GTP-bound form (Zhou et al, 2006; Wright et al, 2011). ARL3 binds UNC119B in a GTP-dependent fashion and is required for the ciliary localization of NPHP3 and CYS1. Upon GTPase activation, ARL3 promotes the transfer of the myristoylated cargo into the ciliary membrane (Wright et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
16525022	Arl2 and Arl3 regulate different microtubule-dependent processes Zhou, C, Li, Y, Kahn, RA, Marcus, AI, Cunningham, L	Mol. Biol. Cell	2006
22085962	An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium Sengupta, P, Kwong, M, Baye, LM, Sang, L, Sheffield, VC, Wright, KJ, Slusarski, DC, Jackson, PK, Pretorius, PR, Wang, W, Mukhopadhyay, S, Olivier-Mason, A	Genes Dev.	2011