ARL3:GTP binds the UNC119B complex

Stable Identifier
R-HSA-5624133
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ARL3 is an ARF-like small GTPase that is localized to the cilium in both the GDP- and the GTP-bound form (Zhou et al, 2006; Wright et al, 2011). ARL3 binds UNC119B in a GTP-dependent fashion and is required for the ciliary localization of NPHP3 and CYS1. Upon GTPase activation, ARL3 promotes the transfer of the myristoylated cargo into the ciliary membrane (Wright et al, 2011).

Literature References
PubMed ID Title Journal Year
22085962 An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

Wright, KJ, Baye, LM, Olivier-Mason, A, Mukhopadhyay, S, Sang, L, Kwong, M, Wang, W, Pretorius, PR, Sheffield, VC, Sengupta, P, Slusarski, DC, Jackson, PK

Genes Dev. 2011
16525022 Arl2 and Arl3 regulate different microtubule-dependent processes

Zhou, C, Cunningham, L, Marcus, AI, Li, Y, Kahn, RA

Mol. Biol. Cell 2006
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