RP2 is an ARL3 GAP that is localized to the cilium and plays a role in trafficking proteins from the Golgi to the ciliary membrane (Veltel et al, 2008a; Hurd et al, 2011; Evans et al, 2010; Wright et al, 2011). RP2 forms a ternary complex with UNC119B and ARL3, activating the ARL3 GTPase activity and promoting the release of UNC119B (Veltel et al, 2008b; Wright et al, 2011; Kuhnel et al, 2006; reviewed in Schwarz et al, 2012; Li et al, 2012)
Cheetham, ME, Wolfrum, U, Schwarz, N, Hardcastle, AJ, Nagel-Wolfrum, K, Evans, RJ
Schlichting, I, Kühnel, K, Wittinghofer, A, Veltel, S
Eisenacher, E, Gasper, R, Wittinghofer, A, Veltel, S
Hurd, TW, Margolis, BL, Fan, S
Ling, K, Hu, J, Li, Y
Sengupta, P, Kwong, M, Baye, LM, Sang, L, Sheffield, VC, Wright, KJ, Slusarski, DC, Jackson, PK, Pretorius, PR, Wang, W, Mukhopadhyay, S, Olivier-Mason, A
Kravchenko, A, Ismail, S, Wittinghofer, A, Veltel, S
Cheetham, ME, Schwarz, N, Hardcastle, AJ
GTPase activator activity of RP2 [cilium]
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