Reactome | RP2 activates the GTPase activity of ARL3

RP2 activates the GTPase activity of ARL3

Stable Identifier

R-HSA-5638007

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cilium

ReviewStatus

5/5

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RP2 activates the GTPase activity of ARL3

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RP2 is an ARL3 GAP that is localized to the cilium and plays a role in trafficking proteins from the Golgi to the ciliary membrane (Veltel et al, 2008a; Hurd et al, 2011; Evans et al, 2010; Wright et al, 2011). RP2 forms a ternary complex with UNC119B and ARL3, activating the ARL3 GTPase activity and promoting the release of UNC119B (Veltel et al, 2008b; Wright et al, 2011; Kuhnel et al, 2006; reviewed in Schwarz et al, 2012; Li et al, 2012)

Literature References

PubMed ID	Title	Journal	Year
20106869	The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium Cheetham, ME, Wolfrum, U, Schwarz, N, Hardcastle, AJ, Nagel-Wolfrum, K, Evans, RJ	Hum. Mol. Genet.	2010
16472755	Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3 Schlichting, I, Kühnel, K, Wittinghofer, A, Veltel, S	Structure	2006
18376416	The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3 Eisenacher, E, Gasper, R, Wittinghofer, A, Veltel, S	Nat. Struct. Mol. Biol.	2008
21285245	Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2 Hurd, TW, Margolis, BL, Fan, S	J. Cell. Sci.	2011
22389062	The emerging role of Arf/Arl small GTPases in cilia and ciliopathies Ling, K, Hu, J, Li, Y	J. Cell. Biochem.	2012
22085962	An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium Sengupta, P, Kwong, M, Baye, LM, Sang, L, Sheffield, VC, Wright, KJ, Slusarski, DC, Jackson, PK, Pretorius, PR, Wang, W, Mukhopadhyay, S, Olivier-Mason, A	Genes Dev.	2011
18588884	Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex Kravchenko, A, Ismail, S, Wittinghofer, A, Veltel, S	FEBS Lett.	2008
22884633	Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins Cheetham, ME, Schwarz, N, Hardcastle, AJ	Vision Res.	2012