RP2 activates the GTPase activity of ARL3

Stable Identifier
R-HSA-5638007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RP2 is an ARL3 GAP that is localized to the cilium and plays a role in trafficking proteins from the Golgi to the ciliary membrane (Veltel et al, 2008a; Hurd et al, 2011; Evans et al, 2010; Wright et al, 2011). RP2 forms a ternary complex with UNC119B and ARL3, activating the ARL3 GTPase activity and promoting the release of UNC119B (Veltel et al, 2008b; Wright et al, 2011; Kuhnel et al, 2006; reviewed in Schwarz et al, 2012; Li et al, 2012)

Literature References
PubMed ID Title Journal Year
16472755 Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3

K├╝hnel, K, Veltel, S, Schlichting, I, Wittinghofer, A

Structure 2006
20106869 The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium

Evans, RJ, Schwarz, N, Nagel-Wolfrum, K, Wolfrum, U, Hardcastle, AJ, Cheetham, ME

Hum. Mol. Genet. 2010
18376416 The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3

Veltel, S, Gasper, R, Eisenacher, E, Wittinghofer, A

Nat. Struct. Mol. Biol. 2008
21285245 Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2

Hurd, TW, Fan, S, Margolis, BL

J. Cell. Sci. 2011
22389062 The emerging role of Arf/Arl small GTPases in cilia and ciliopathies

Li, Y, Ling, K, Hu, J

J. Cell. Biochem. 2012
22085962 An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

Wright, KJ, Baye, LM, Olivier-Mason, A, Mukhopadhyay, S, Sang, L, Kwong, M, Wang, W, Pretorius, PR, Sheffield, VC, Sengupta, P, Slusarski, DC, Jackson, PK

Genes Dev. 2011
18588884 Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

Veltel, S, Kravchenko, A, Ismail, S, Wittinghofer, A

FEBS Lett. 2008
22884633 Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins

Schwarz, N, Hardcastle, AJ, Cheetham, ME

Vision Res. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activator activity of RP2 [cilium]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!