ARL3 hydrolyzes GTP

Stable Identifier
Reaction [transition]
Homo sapiens
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RP2 is an ARL3 GAP that is localized to the cilium and plays a role in trafficking proteins from the Golgi to the ciliary membrane (Veltel et al, 2008a; Hurd et al, 2011; Evans et al, 2010; Wright et al, 2011). RP2 forms a ternary complex with UNC119B and ARL3, activating the ARL3 GTPase activity and promoting the release of UNC119B (Veltel et al, 2008b; Wright et al, 2011; Kuhnel et al, 2006; reviewed in Schwarz et al, 2012; Li et al, 2012)
Literature References
PubMed ID Title Journal Year
20106869 The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium

Cheetham, ME, Wolfrum, U, Schwarz, N, Hardcastle, AJ, Nagel-Wolfrum, K, Evans, RJ

Hum. Mol. Genet. 2010
16472755 Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3

Schlichting, I, K├╝hnel, K, Wittinghofer, A, Veltel, S

Structure 2006
18376416 The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3

Eisenacher, E, Gasper, R, Wittinghofer, A, Veltel, S

Nat. Struct. Mol. Biol. 2008
21285245 Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2

Hurd, TW, Margolis, BL, Fan, S

J. Cell. Sci. 2011
22389062 The emerging role of Arf/Arl small GTPases in cilia and ciliopathies

Ling, K, Hu, J, Li, Y

J. Cell. Biochem. 2012
22085962 An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

Sengupta, P, Kwong, M, Baye, LM, Sang, L, Sheffield, VC, Wright, KJ, Slusarski, DC, Jackson, PK, Pretorius, PR, Wang, W, Mukhopadhyay, S, Olivier-Mason, A

Genes Dev. 2011
18588884 Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

Kravchenko, A, Ismail, S, Wittinghofer, A, Veltel, S

FEBS Lett. 2008
22884633 Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins

Cheetham, ME, Schwarz, N, Hardcastle, AJ

Vision Res. 2012
Catalyst Activity

GTPase activity of RP2:ARL3:GTP:UNC119B(active) [cilium]

Orthologous Events
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