Reactome | UNC119B binds myristoylated proteins

UNC119B binds myristoylated proteins

Stable Identifier

R-HSA-5624131

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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UNC119B is an ARL3 effector that binds directly to the myristoyl moieties at glycine 2 of NPHP3 and CYS1 (Wright et al, 2011). Myristoylation is required for the ciliary localization of these proteins (Wright et al, 2011; Tao et al, 2006), and both mutation of the glycine 2 myristoylation target in NPHP3 and siRNA knockdown of UNC119B dramatically reduce the ciliary localization of NPHP3 and CYS1 (Tao et al, 2006; Wright et al, 2011; reviewed in Schwarz et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
19850956	Cystin localizes to primary cilia via membrane microdomains and a targeting motif Tao, B, Bu, S, Yang, Z, Siroky, B, Kappes, JC, Kispert, A, Guay-Woodford, LM	J. Am. Soc. Nephrol.	2009
22085962	An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium Wright, KJ, Baye, LM, Olivier-Mason, A, Mukhopadhyay, S, Sang, L, Kwong, M, Wang, W, Pretorius, PR, Sheffield, VC, Sengupta, P, Slusarski, DC, Jackson, PK	Genes Dev.	2011
22884633	Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins Schwarz, N, Hardcastle, AJ, Cheetham, ME	Vision Res.	2012