UNC119B binds myristoylated proteins

Stable Identifier
Reaction [binding]
Homo sapiens
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UNC119B is an ARL3 effector that binds directly to the myristoyl moieties at glycine 2 of NPHP3 and CYS1 (Wright et al, 2011). Myristoylation is required for the ciliary localization of these proteins (Wright et al, 2011; Tao et al, 2006), and both mutation of the glycine 2 myristoylation target in NPHP3 and siRNA knockdown of UNC119B dramatically reduce the ciliary localization of NPHP3 and CYS1 (Tao et al, 2006; Wright et al, 2011; reviewed in Schwarz et al, 2012).

Literature References
PubMed ID Title Journal Year
19850956 Cystin localizes to primary cilia via membrane microdomains and a targeting motif

Kispert, A, Tao, B, Siroky, B, Guay-Woodford, LM, Kappes, JC, Bu, S, Yang, Z

J. Am. Soc. Nephrol. 2009
22085962 An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

Sengupta, P, Kwong, M, Baye, LM, Sang, L, Sheffield, VC, Wright, KJ, Slusarski, DC, Jackson, PK, Pretorius, PR, Wang, W, Mukhopadhyay, S, Olivier-Mason, A

Genes Dev. 2011
22884633 Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins

Cheetham, ME, Schwarz, N, Hardcastle, AJ

Vision Res. 2012
Orthologous Events
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