UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium

Stable Identifier
R-HSA-5624132
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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UNC119B promotes the translocation of myristoylated NPHP3 from the ER membrane to the cilium by an unknown mechanism. Ciliary localization depends both on myristoylation and UNC119B, as mutation of the glycine 2 acceptor site or siRNA knockdown of UNC119B drastically reduces the amount of NPHP3 or CYS1 in the cilium (Wright et al, 2011).

Literature References
PubMed ID Title Journal Year
22085962 An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

Wright, KJ, Baye, LM, Olivier-Mason, A, Mukhopadhyay, S, Sang, L, Kwong, M, Wang, W, Pretorius, PR, Sheffield, VC, Sengupta, P, Slusarski, DC, Jackson, PK

Genes Dev. 2011
Participants
Participant Of
Orthologous Events
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