IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol

Stable Identifier
R-HSA-139854
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Transport of Ca++ from platelet dense tubular system to cytoplasm
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The IP3 receptor (IP3R) is an intracellular calcium release channel that mobilizes Ca2+ from internal stores in the ER to the cytoplasm. Though its activity is stimulated by IP3, the principal activator of the IP3R is Ca2+. This process of calcium-induced calcium release is central to the mechanism of Ca2+ signalling. The effect of cytosolic Ca2+ on IP3R is complex: it can be both stimulatory and inhibitory and can the effect varies between IP3R isoforms. In general, the IP3Rs have a bell-shaped Ca2+ dependence when treated with low concentrations of IP3; low concentrations of Ca2+ (100–300 nM) are stimulatory but above 300 nM, Ca2+ becomes inhibitory and switches the channel off. The stimulatory effect of IP3 is to relieve Ca2+ inhibition of the channel, enabling Ca2+ activation sites to gate it.
Functionally the IP3 receptor is believed to be tetrameric, with results indicating that the tetramer is composed of 2 pairs of protein isoforms.

Literature References
PubMed ID Title Journal Year
1693919 Receptor-activated single channels in intact human platelets

Mahaut-Smith, MP, Sage, SO, Rink, TJ

J Biol Chem 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium channel activity of IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane]
Physical Entity
Activity
Orthologous Events
Created