Reactome | AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it

AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it

Stable Identifier

R-HSA-5226904

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Putative adenosylhomocysteinase 2 (AHCYL1 aka adenosylhomocysteine hydrolase-like protein 1) (Dekker et al. 2002) possesses 50% homology to adenosylhomocysteine hydrolase (AHCY), an enzyme important for metabolizing S-adenosyl-l-homocysteine. AHCYL1 can bind to the inositol 1,4,5-trisphosphate receptor (ITPR1) tetramer, suggesting that AHCYL1 is involved in modulating intracellular calcium release (Cooper et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
11904675	Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation Dekker, JW, Budhia, S, Angel, NZ, Cooper, BJ, Clark, GJ, Hart, DN, Kato, M	Immunogenetics	2002
16754674	Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling Cooper, BJ, Key, B, Carter, A, Angel, NZ, Hart, DN, Kato, M	J. Biol. Chem.	2006