AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it

Stable Identifier
R-HSA-5226904
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Putative adenosylhomocysteinase 2 (AHCYL1 aka adenosylhomocysteine hydrolase-like protein 1) (Dekker et al. 2002) possesses 50% homology to adenosylhomocysteine hydrolase (AHCY), an enzyme important for metabolizing S-adenosyl-l-homocysteine. AHCYL1 can bind to the inositol 1,4,5-trisphosphate receptor (ITPR1) tetramer, suggesting that AHCYL1 is involved in modulating intracellular calcium release (Cooper et al. 2006).

Literature References
PubMed ID Title Journal Year
16754674 Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling

Cooper, BJ, Key, B, Carter, A, Angel, NZ, Hart, DN, Kato, M

J. Biol. Chem. 2006
11904675 Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation

Dekker, JW, Budhia, S, Angel, NZ, Cooper, BJ, Clark, GJ, Hart, DN, Kato, M

Immunogenetics 2002
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