KCNJ11:ABCC9 transports K+ from extracellular region to cytosol

Stable Identifier
R-HSA-5678261
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ATP-sensitive inward rectifier potassium channel 11 (KCNJ11) is an inward rectifier potassium channel, favouring potassium flow into the cell rather than out of it. KCNJ11 can complex with ATP-binding cassette sub-family member 9 (ABCC9) to form cardiac and smooth muscle-type K+(ATP) channels. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (Babenko et al. 1998, Tammaro & Ashcroft 2007).

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inward rectifier potassium channel activity of KCNJ11:ABCC9 [plasma membrane]

Physical Entity
KCNJ11:ABCC9 [plasma membrane] (Homo sapiens)
Activity
inward rectifier potassium channel activity (GO:0005242)
Orthologous Events
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Bos taurus)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Canis familiaris)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Danio rerio)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Drosophila melanogaster)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Gallus gallus)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Mus musculus)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Rattus norvegicus)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Sus scrofa)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-02-23)
Reviewed
Moitra, K  (2015-04-28)
Created
Jassal, B  (2015-02-23)
Cite Us!