Reactome | KCNJ11:ABCC9 transports K+ from extracellular region to cytosol

KCNJ11:ABCC9 transports K+ from extracellular region to cytosol

Stable Identifier

R-HSA-5678261

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

4/5

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KCNJ11:ABCC9 transports K+ from extracellular region to cytosol

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ATP-sensitive inward rectifier potassium channel 11 (KCNJ11) is an inward rectifier potassium channel, favouring potassium flow into the cell rather than out of it. KCNJ11 can complex with ATP-binding cassette sub-family member 9 (ABCC9) to form cardiac and smooth muscle-type K+(ATP) channels. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (Babenko et al. 1998, Tammaro & Ashcroft 2007).

Literature References

PubMed ID	Title	Journal	Year
17855752	A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit Tammaro, P, Ashcroft, FM	J. Physiol. (Lond.)	2007
9831708	Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells Babenko, AP, Gonzalez, G, Aguilar-Bryan, L, Bryan, J	Circ. Res.	1998