Reactome | PRKACA phosphorylates PLN

PRKACA phosphorylates PLN

Stable Identifier

R-HSA-5617182

Type

Reaction [transition]

Species

Homo sapiens

Compartment

sarcoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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Cardiac muscle phospholamban (PLN aka PLB) modulates cardiac contractility by inhibiting the sarcoplasmic reticulum calcium pump (ATP2A2 aka SERCA). This process is dynamically regulated by beta-adrenergic stimulation and phosphorylation of PLN. Protein kinase A (PRKACA) is able to phosphorylate PLN at serine 16, relieving its inhibition of ATP2A2 and modulating cardiac contractility (Glaves et al. 2011, Ceholski et al. 2012). The ATP2B4:NOS1 complex, via cAMP, increases PRKACA activity, thereby regulating the response of the heart to beta-adrenergic agonists.

Literature References

PubMed ID	Title	Journal	Year
21108950	Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump Glaves, JP, Trieber, CA, Ceholski, DK, Stokes, DL, Young, HS	J. Mol. Biol.	2011
22707725	Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A Ceholski, DK, Trieber, CA, Holmes, CF, Young, HS	J. Biol. Chem.	2012