PRKACA phosphorylates PLN

Stable Identifier
R-HSA-5617182
Type
Reaction [transition]
Species
Homo sapiens
Compartment
sarcoplasmic reticulum membrane, cytosol
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PRKACA phosphorylates PLN
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Cardiac muscle phospholamban (PLN aka PLB) modulates cardiac contractility by inhibiting the sarcoplasmic reticulum calcium pump (ATP2A2 aka SERCA). This process is dynamically regulated by beta-adrenergic stimulation and phosphorylation of PLN. Protein kinase A (PRKACA) is able to phosphorylate PLN at serine 16, relieving its inhibition of ATP2A2 and modulating cardiac contractility (Glaves et al. 2011, Ceholski et al. 2012). The ATP2B4:NOS1 complex, via cAMP, increases PRKACA activity, thereby regulating the response of the heart to beta-adrenergic agonists.

Literature References
PubMed ID Title Journal Year
22707725 Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A

Ceholski, DK, Trieber, CA, Holmes, CF, Young, HS

J. Biol. Chem. 2012
21108950 Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump

Glaves, JP, Trieber, CA, Ceholski, DK, Stokes, DL, Young, HS

J. Mol. Biol. 2011
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cAMP-dependent protein kinase activity of PRKACA [cytosol]
Physical Entity
PRKACA [cytosol]
Activity
cAMP-dependent protein kinase activity (0004691)
This event is regulated
Positively by
Orthologous Events
PRKACA phosphorylates PLN (Canis familiaris)
PRKACA phosphorylates PLN (Danio rerio)
PRKACA phosphorylates PLN (Mus musculus)
PRKACA phosphorylates PLN (Rattus norvegicus)
Authored
Jassal, B  (2014-08-05)
Reviewed
Colotti, G  (2015-11-09)
Created
Jassal, B  (2014-08-05)