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KCNJ11:ABCC9 binds nicorandil
Stable Identifier
R-HSA-9691566
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
KCNJ11:ABCC9 binds nicorandil (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Nicorandil, a nicotinamide derivative, is an oral antianginal drug possessing a nitrate moiety in its structure. This drug is an effective and well-tolerated treatment for various types of angina pectoris. Its structure is characterised by a dual mechanism of action. The nicotinamide moiety acts as an agonist for ATP-sensitive inward rectifier potassium channel 11 (KCNJ11, in complex with its regulatory subunit ABCC9) (Hambrock et al. 1999) and the nitrate group explains its nitrate-like properties (Kinoshita & Sakai 1990, Ahmed 2019).
Literature References
PubMed ID
Title
Journal
Year
10220561
ATP-Sensitive K+ channel modulator binding to sulfonylurea receptors SUR2A and SUR2B: opposite effects of MgADP
Löffler-Walz, C
,
Delabar, U
,
Quast, U
,
Horio, Y
,
Hambrock, A
,
Kloor, D
,
Kurachi, Y
Mol. Pharmacol.
1999
Participants
Input
KCNJ11:ABCC9 [plasma membrane]
(Homo sapiens)
nicorandil [extracellular region]
Output
KCNJ11:ABCC9:nicorandil [plasma membrane]
(Homo sapiens)
Participates
as an event of
Ion homeostasis (Homo sapiens)
Orthologous Events
KCNJ11:ABCC9 binds nicorandil (Bos taurus)
KCNJ11:ABCC9 binds nicorandil (Canis familiaris)
KCNJ11:ABCC9 binds nicorandil (Drosophila melanogaster)
KCNJ11:ABCC9 binds nicorandil (Gallus gallus)
KCNJ11:ABCC9 binds nicorandil (Mus musculus)
KCNJ11:ABCC9 binds nicorandil (Rattus norvegicus)
KCNJ11:ABCC9 binds nicorandil (Sus scrofa)
KCNJ11:ABCC9 binds nicorandil (Xenopus tropicalis)
Authored
Jassal, B (2020-06-17)
Reviewed
Huddart, R (2022-03-01)
Created
Jassal, B (2020-06-17)
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