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TXNRD1 [cytosol]
Stable Identifier
R-HSA-73531
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
thioredoxin reductase 1, Thioredoxin reductase, cytoplasmic precursor (EC 1.8.1.9) (TR), Thioredoxin reductase, cytoplasmic precursor , TR, TR1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
AcK-NFE2L2-dependent TXNRD1 gene expression (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of diphtheria toxin (Homo sapiens)
DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se (Homo sapiens)
SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Metabolism of ingested MeSeO2H into MeSeH (Homo sapiens)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of TXNRD1 (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16881 TXNRD1
Gene Names
TXNRD1, GRIM12, KDRF
Chain
chain:1-649
Reference Genes
COSMIC (genes):TXNRD1 TXNRD1
dbSNP Gene:7296 TXNRD1
ENSEMBL:ENSG00000198431 TXNRD1
Participates
as an output of
Expression of TXNRD1 (Homo sapiens)
AcK-NFE2L2-dependent TXNRD1 gene expression (Homo sapiens)
as a component of
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
This entity regulates
Positively
DT fragment B transports DT fragment A from target cell endosome membrane
(Homo sapiens)
Inferred To
TXNRD1 [cytosol]
(Bos taurus)
TXNRD1 [cytosol]
(Caenorhabditis elegans)
TXNRD1 [cytosol]
(Gallus gallus)
TXNRD1 [cytosol]
(Mus musculus)
TXNRD1 [cytosol]
(Plasmodium falciparum)
TXNRD1 [cytosol]
(Rattus norvegicus)
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
CAV1 [early endosome membrane]
(R-HSA-5368451)
0.632
4
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