Reactome | APBA1 [cytosol]

APBA1 [cytosol]

Stable Identifier

R-HSA-5336459

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Amyloid beta A4 precursor protein-binding family A member 1, APBA1_HUMAN, MINT1

Locations in the PathwayBrowser for interactor UniProt:K9N5R3 VEMP

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External Reference Information

External Reference

UniProt:Q02410 APBA1

Gene Names

APBA1, MINT1, X11

Chain

chain:1-837

Reference Genes

BioGPS Gene:320 APBA1

COSMIC - genes:APBA1 APBA1

CTD Gene:320 APBA1

dbSNP Gene:320 APBA1

ENSEMBL:ENSG00000107282 APBA1

HGNC:578 APBA1

KEGG:hsa:320 APBA1

Monarch:320 APBA1

NCBI Gene:320 APBA1

OMIM:602414 APBA1

UCSC:Q02410 APBA1

Reference Transcript

Participates

as an input of

LIN7, CASK and APBA1 bind (Homo sapiens)

as a component of

as a candidate of

MINT1,2,(3) [cytosol] (Homo sapiens)

Inferred To

apba1b [cytosol] (Danio rerio)

Apba1 [cytosol] (Mus musculus)

Apba1 [cytosol] (Rattus norvegicus)

APBA1 [cytosol] (Bos taurus)

APBA1 [cytosol] (Canis familiaris)

APBA1 [cytosol] (Gallus gallus)

APBA1 [cytosol] (Sus scrofa)

apba1 [cytosol] (Xenopus tropicalis)

Homologues of APBA1 [cytosol] (Drosophila melanogaster)

X11L [cytosol] (Drosophila melanogaster)

X11Lbeta [cytosol] (Drosophila melanogaster)

lin-10 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_016870159.1, NP_001154.2, XP_054218834.1, XP_054218833.1, XP_054218836.1, XP_047279256.1, XP_011516919.1, XP_054218835.1, XP_005252025.1

OpenTargets

ENSG00000107282

ENSEMBL

ENST00000265381, ENSG00000107282, ENSP00000265381

HPA

ENSG00000107282-APBA1

GeneCards

APBA1

PRO

Q02410

Pharos - Targets

Q02410

GlyGen

Q02410

PDB

1U3B, 1X11, 1Y7N, 1AQC, 1U37, 1U39, 1U38, 1X45

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99767 APBA2	1	APBA2 [cytosol] (R-HSA-6794245)	0.759	5
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.759	6
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.729	5
UniProt:O14936 CASK	1	CASK [cytosol] (R-HSA-373631)	0.702	5
UniProt:P49768 PSEN1	6	PSEN1(299-467) [plasma membrane] (R-HSA-2534245) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [plasma membrane] (R-HSA-201606)	0.697	4
UniProt:K9N5R3 VEMP			0.609	2
UniProt:Q02410 APBA1	1	APBA1 [cytosol] (R-HSA-5336459)	0.592	3
UniProt:P78352 DLG4	3	DLG4 [plasma membrane] (R-HSA-202135) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [cytosol] (R-HSA-6794267)	0.59	4
UniProt:Q9BZL6 PRKD2	1	PRKD2 [cytosol] (R-HSA-58214)	0.59	4
UniProt:O14910 LIN7A	2	LIN7A [plasma membrane] (R-HSA-5216076) LIN7A [transport vesicle membrane] (R-HSA-9610413)	0.59	4
UniProt:Q12959 DLG1	4	DLG1 [plasma membrane] (R-HSA-375977) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [cytosol] (R-HSA-416332)	0.59	6
UniProt:Q96DR7 ARHGEF26	1	ARHGEF26 [cytosol] (R-HSA-8873912)	0.59	4
UniProt:P51812 RPS6KA3	7	p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) RPS6KA3 [cytosol] (R-HSA-444250) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [nucleoplasm] (R-HSA-199869)	0.59	3
UniProt:Q7Z628 NET1	1	NET1 [cytosol] (R-HSA-3006799)	0.59	2
UniProt:Q99569 PKP4	2	PKP4 [cornified envelope] (R-HSA-8847721) PKP4 [plasma membrane] (R-HSA-6814401)	0.59	3
UniProt:Q7L4I2 RSRC2			0.59	2
UniProt:Q9HAP6 LIN7B	2	LIN7B [transport vesicle membrane] (R-HSA-9610415) LIN7B [plasma membrane] (R-HSA-5216107)	0.527	3
UniProt:P06463 VE6			0.525	4

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