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ARF1 [Golgi membrane]
Stable Identifier
R-HSA-199971
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Arf1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Homo sapiens)
AP-1 Complex:Arf1-GTP:Clathrin Triskelion:Nonameric complex [trans-Golgi network membrane] (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
TGN-lysosomal vesicle coat assembly (Homo sapiens)
AP-1 Complex:Arf1-GTP:Clathrin Triskelion:Nonameric complex [trans-Golgi network membrane] (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the Golgi membrane (Homo sapiens)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Homo sapiens)
ARF1/3:GTP:PI4KB [Golgi membrane] (Homo sapiens)
ARF1/3:GTP [Golgi membrane] (Homo sapiens)
ARF1:GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
PI4KB binds to ARF1/3:GTP at the Golgi membrane (Homo sapiens)
ARF1/3:GTP [Golgi membrane] (Homo sapiens)
ARF1:GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
ARF1/3:GTP:PI4KB [Golgi membrane] (Homo sapiens)
ARF1/3:GTP [Golgi membrane] (Homo sapiens)
ARF1:GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PLEKHA3,8 bind PI4P, ARF1 (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
ARF1:PLEKHA3,8:PI4P [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Intra-Golgi traffic (Homo sapiens)
ARF1:GTP binds Golgin TRIP11 (Homo sapiens)
ARF1:GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
ARF1:GTP:TRIP11:cargo [Golgi membrane] (Homo sapiens)
ARF1:GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
CYTH proteins bind ARF1:GTP (Homo sapiens)
ARF1:GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
ARF1:GTP:CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
ARF1:GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
CYTH proteins stimulate ARF1 GTPase activity (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
ARF1:GDP:CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
Arf1-GDP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
ARF1:GTP:CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
ARF1:GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
trans-Golgi Network Coat Assembly (Homo sapiens)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
Lysosome Vesicle Biogenesis (Homo sapiens)
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
Lysosome Destined Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Homo sapiens)
Lysosome Destined Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
trans-Golgi Network Coat Activation (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P84077 ARF1
Gene Names
ARF1
Chain
initiator methionine:1, chain:2-181
Reference Genes
BioGPS Gene:375 ARF1
COSMIC (genes):ARF1 ARF1
CTD Gene:375 ARF1
dbSNP Gene:375 ARF1
ENSEMBL:ENSG00000143761 ARF1
HGNC:652 ARF1
KEGG Gene (Homo sapiens):375 ARF1
Monarch:375 ARF1
NCBI Gene:375 ARF1
OMIM:103180 ARF1
UCSC:P84077 ARF1
Reference Transcript
RefSeq:NM_001024226.1 ARF1
RefSeq:NM_001024227.1 ARF1
RefSeq:NM_001658.3 ARF1
RefSeq:NM_001024228.1 ARF1
Other Identifiers
0000840600
11719759_s_at
16678303
18670609
18670610
18670615
18670616
18670617
18670618
18670619
200065_PM_s_at
200065_s_at
208750_s_at
2383733
2383734
2383735
2383736
2383737
2383754
2383755
2383756
2383758
2383759
2383761
2383762
2383763
2383764
2383765
2383766
2383767
2383768
2383769
244504_3p_x_at
244504_x_at
33987_at
375
7892830
7893592
7893609
7894011
7894336
7894413
7894767
7894808
7895084
7895110
7895484
7895881
7896158
7896375
7896586
7896657
7910229
A_23_P201086
A_24_P190894
A_24_P259490
GE63168
GO:0000139
GO:0000166
GO:0000278
GO:0000287
GO:0002090
GO:0002376
GO:0003674
GO:0003723
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005768
GO:0005770
GO:0005777
GO:0005778
GO:0005794
GO:0005802
GO:0005829
GO:0005886
GO:0005925
GO:0006629
GO:0006661
GO:0006810
GO:0006878
GO:0006886
GO:0006892
GO:0007010
GO:0007015
GO:0007034
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0009058
GO:0012505
GO:0014069
GO:0015031
GO:0016020
GO:0016192
GO:0019003
GO:0019886
GO:0019904
GO:0022607
GO:0030017
GO:0030054
GO:0030137
GO:0030154
GO:0030234
GO:0031252
GO:0031410
GO:0032991
GO:0034315
GO:0034330
GO:0034379
GO:0035722
GO:0042592
GO:0043005
GO:0043167
GO:0043226
GO:0044403
GO:0045202
GO:0045807
GO:0045956
GO:0048471
GO:0048856
GO:0050690
GO:0050714
GO:0051301
GO:0055085
GO:0055108
GO:0060292
GO:0060999
GO:0061024
GO:0065003
GO:0070062
GO:0070142
GO:0097061
GO:0097212
GO:0098586
GO:0098974
GO:0098978
GO:1902307
GO:1902824
GO:1902953
GO:1903725
GO:1990386
GO:1990583
HMNXSV003032236
Hs.282187.0.A1_3p_x_at
Hs.74571.0.A1_3p_a_at
ILMN_1661458
ILMN_1802203
ILMN_2330948
M84332_at
PH_hs_0023485
TC01001884.hg
g3360490_3p_a_at
Participates
as a component of
Arf1-GDP [Golgi membrane] (Homo sapiens)
ARF1:PLEKHA3,8:PI4P [Golgi membrane] (Homo sapiens)
Arf1-GTP [Golgi membrane] (Homo sapiens)
ARF1:GTP [Golgi membrane] (Homo sapiens)
as an input of
PLEKHA3,8 bind PI4P, ARF1 (Homo sapiens)
Other forms of this molecule
ARF1 [cytosol]
Inferred To
ARF2 [Golgi membrane]
(Saccharomyces cerevisiae)
Arf79F [Golgi membrane]
(Drosophila melanogaster)
arfA [Golgi membrane]
(Dictyostelium discoideum)
Arf1 [Golgi membrane]
(Mus musculus)
Arf1 [Golgi membrane]
(Rattus norvegicus)
arf-3 [Golgi membrane]
(Caenorhabditis elegans)
arf1 [Golgi membrane]
(Schizosaccharomyces pombe)
arf2a [Golgi membrane]
(Danio rerio)
faxc [Golgi membrane]
(Xenopus tropicalis)
Homologues of ARF1 [Golgi membrane]
(Saccharomyces cerevisiae)
ARF1 [Golgi membrane]
(Bos taurus)
ARF1 [Golgi membrane]
(Canis familiaris)
ARF1 [Golgi membrane]
(Gallus gallus)
ARF1 [Golgi membrane]
(Plasmodium falciparum)
ARF1 [Golgi membrane]
(Saccharomyces cerevisiae)
ARF1 [Golgi membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001019398.1
,
NP_001019399.1
,
NP_001649.1
,
NP_001019397.1
OpenTargets
ENSG00000143761
ZINC - Substances
ARF1_HUMAN
ZINC target
P84077
PRO
P84077
PDB
6DFF
,
6D83
,
6CRI
,
4HMY
,
7MGE
,
6CM9
,
1U81
,
6D84
,
6FAE
,
1HUR
,
3O47
,
1RE0
HPA
ENSG00000143761-ARF1
GeneCards
P84077
Ensembl
ENST00000541182
,
ENST00000272102
,
ENST00000540651
,
ENSP00000272102
,
ENSP00000440005
,
ENSP00000442980
,
ENSG00000143761
Pharos - Targets
P84077
ZINC - Predictions - Purchasable
ARF1_HUMAN
Orphanet
27691
HMDB Protein
HMDBP01962
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99418 CYTH2
2
CYTH2 [cytosol]
(R-HSA-8847831)
CYTH2 [Golgi membrane]
(R-HSA-8847829)
0.722
5
UniProt:P53367 ARFP1
0.524
2
UniProt:P60880 SNAP25
7
SNAP25(1-197) [plasma membrane]
(R-HSA-3004546)
SNAP25(198-206) [cytosol]
(R-HSA-5244499)
SNAP25(1-198) [plasma membrane]
(R-HSA-3004550)
SNAP25(199-206) [cytosol]
(R-HSA-5244501)
SNAP25 [tertiary granule membrane]
(R-HSA-6806142)
SNAP25 [specific granule membrane]
(R-HSA-6806154)
SNAP25 [plasma membrane]
(R-HSA-2029017)
0.512
5
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.488
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
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