BoNT/C LC cleaves target cell SNAP25

Stable Identifier
R-HSA-194793
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
cytosol, plasma membrane
Synonyms
BoNT Light Chain Type C1 cleaves SNAP-25
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BoNT/C LC cleaves target cell SNAP25
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Botulinum toxin type C light chain (BoNT/C LC), in the cytosol of a target cell, catalyzes the removal of a carboxyterminal peptide from synaptosomal associated protein 25 (SNAP25). BoNT/C LC is a zinc metalloprotease (Foran et al. 1994; Vaidyanathan et al. 1999). SNAP25 is associated with the cytosolic face of the target cell plasma membrane where it forms part of a complex required for synaptic vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release (Sudhof et al, 1993; Sudhof 2004).

Literature References
PubMed ID Title Journal Year
8402889 Membrane fusion machinery: insights from synaptic proteins

Südhof, TC, De Camilli, P, Niemann, H, Jahn, R

Cell 1993
8611567 Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release

Foran, P, Lawrence, GW, Shone, CC, Foster, KA, Dolly, JO

Biochemistry 1996
9886085 Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage

Vaidyanathan, VV, Yoshino, K, Jahnz, M, Dorries, C, Bade, S, Nauenburg, S, Niemann, H, Binz, T

J Neurochem 1999
15217342 The synaptic vesicle cycle

Südhof, TC

Annu Rev Neurosci 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of BoNT/C LC:Zn2+ [cytosol]
Physical Entity
BoNT/C LC:Zn2+ [cytosol]
Activity
metalloendopeptidase activity (0004222)
Disease
Name Identifier Synonyms
botulism 11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Authored
Krupa, S  (2006-06-15)
Gopinathrao, G  (2006-06-15)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
Gopinathrao, G  (2007-03-27)