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ARF1 [cytosol]
Stable Identifier
R-HSA-200826
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Arf1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
Nef Mediated CD4 Down-regulation (Homo sapiens)
Formation of a Nef:ARF1:CD4 complex (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
Arf1:Nef:endosomal CD4 [early endosome membrane] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Homo sapiens)
Arf1-GDP [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of ADP-ribosylation factor 1 (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
Active ARF recruits coatomer (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
GBF1 recruits ARF:GDP to the ERGIC (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
GBF1 stimulates ARF nucleotide exchange (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
Active ARF recruits coatomer (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
GBF1 recruits ARF:GDP to the ERGIC (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
GBF1 stimulates ARF nucleotide exchange (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
Active ARF recruits coatomer to the Golgi (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
GBF1 recruits ARF:GDP to the Golgi (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GDP [Golgi membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
GBF1 stimulates nucleotide exchange on ARF (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GDP [Golgi membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
trans-Golgi Network Coat Assembly (Homo sapiens)
Arf1-GDP [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
Lysosome Vesicle Biogenesis (Homo sapiens)
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Homo sapiens)
Arf1-GDP [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
trans-Golgi Network Coat Activation (Homo sapiens)
Arf1-GDP [cytosol] (Homo sapiens)
ARF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P84077 ARF1
Gene Names
ARF1
Chain
initiator methionine:, chain:2-181
Reference Genes
BioGPS Gene:375 ARF1
COSMIC (genes):ARF1 ARF1
CTD Gene:375 ARF1
dbSNP Gene:375 ARF1
ENSEMBL:ENSG00000143761 ARF1
HGNC:652 ARF1
KEGG:hsa:375 ARF1
Monarch:375 ARF1
NCBI Gene:375 ARF1
OMIM:103180 ARF1
UCSC:P84077 ARF1
Reference Transcript
RefSeq:NM_001024227.1 ARF1
RefSeq:NM_001024228.1 ARF1
RefSeq:NM_001024226.1 ARF1
RefSeq:NM_001658.3 ARF1
Other Identifiers
11719759_s_at
16656669
16656691
16656693
16656717
16656719
16678303
16678320
18670609
18670610
18670611
18670612
18670613
18670614
18670615
18670616
18670617
18670618
18670619
200065_PM_s_at
200065_s_at
208750_PM_s_at
208750_s_at
2383733
2383734
2383735
2383736
2383737
2383738
2383743
2383744
2383746
2383747
2383748
2383754
2383755
2383756
2383757
2383758
2383759
2383760
2383761
2383762
2383763
2383764
2383765
2383766
2383767
2383768
2383769
244504_3p_x_at
244504_PM_x_at
244504_x_at
33987_at
375
7892830
7893568
7893592
7893609
7894011
7894290
7894336
7894413
7894767
7894808
7895084
7895110
7895484
7895597
7895881
7896158
7896375
7896586
7896657
7910229
A_23_P201086
A_24_P190894
A_24_P259490
GE63168
GO:0000139
GO:0000287
GO:0002090
GO:0003723
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005794
GO:0005829
GO:0005886
GO:0005925
GO:0006878
GO:0006886
GO:0012505
GO:0014069
GO:0015031
GO:0016020
GO:0016192
GO:0016787
GO:0019904
GO:0030017
GO:0031252
GO:0032991
GO:0034315
GO:0043005
GO:0043226
GO:0045202
GO:0060292
GO:0061024
GO:0070062
GO:0097061
GO:0098586
GO:1990386
HMNXSV003032236
Hs.282187.0.A1_3p_at
Hs.282187.0.A1_3p_x_at
Hs.74571.0.A1_3p_a_at
ILMN_1661458
ILMN_1802203
ILMN_2330948
M84332_at
PH_hs_0023485
TC01001884.hg
g3360490_3p_a_at
Participates
as a component of
Arf1-GDP [cytosol] (Homo sapiens)
Arf1:Nef:endosomal CD4 [early endosome membrane] (Homo sapiens)
as an output of
Expression of ADP-ribosylation factor 1 (Homo sapiens)
as an input of
Formation of a Nef:ARF1:CD4 complex (Homo sapiens)
as a candidate of
ARFs [cytosol] (Homo sapiens)
Other forms of this molecule
ARF1 [Golgi membrane]
Inferred To
arrA [cytosol]
(Dictyostelium discoideum)
arrE [cytosol]
(Dictyostelium discoideum)
arrD [cytosol]
(Dictyostelium discoideum)
arf5 [cytosol]
(Xenopus tropicalis)
ARF1 [cytosol]
(Bos taurus)
ARF1 [cytosol]
(Caenorhabditis elegans)
ARF1 [cytosol]
(Canis familiaris)
ARF1 [cytosol]
(Dictyostelium discoideum)
ARF1 [cytosol]
(Drosophila melanogaster)
ARF1 [cytosol]
(Gallus gallus)
ARF1 [cytosol]
(Mus musculus)
ARF1 [cytosol]
(Plasmodium falciparum)
ARF1 [cytosol]
(Rattus norvegicus)
ARF1 [cytosol]
(Saccharomyces cerevisiae)
ARF1 [cytosol]
(Schizosaccharomyces pombe)
ARF1 [cytosol]
(Sus scrofa)
arf1 [cytosol]
(Danio rerio)
arrB [cytosol]
(Dictyostelium discoideum)
Homologues of ARF1 [cytosol]
(Caenorhabditis elegans)
Homologues of ARF1 [cytosol]
(Dictyostelium discoideum)
Homologues of ARF1 [cytosol]
(Plasmodium falciparum)
Homologues of ARF1 [cytosol]
(Saccharomyces cerevisiae)
arrC [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001019399.1
,
NP_001019397.1
,
NP_001019398.1
,
NP_001649.1
OpenTargets
ENSG00000143761
ENSEMBL
ENST00000478336
,
ENSG00000143761
,
ENSP00000272102
,
ENST00000272102
,
ENST00000478424
,
ENSP00000514657
,
ENST00000470558
,
ENSP00000514653
,
ENSP00000514654
ZINC - Substances
ARF1_HUMAN
ZINC target
P84077
PRO
P84077
GlyGen
P84077
PDB
7DN8
,
7MGE
,
7DN9
,
8SDW
,
1U81
,
3O47
,
6CM9
,
6DFF
,
8D4C
,
7UX3
,
8D4D
,
8D4F
,
7R4H
,
6FAE
,
8D4E
,
8D4G
,
1HUR
,
1RE0
,
4HMY
,
8D9W
,
8D9U
,
6D83
,
8D9R
,
6CRI
,
8D9S
,
6D84
HPA
ENSG00000143761-ARF1
GeneCards
ARF1
Pharos - Targets
P84077
Orphanet
ARF1
ZINC - Predictions - Purchasable
ARF1_HUMAN
HMDB Protein
HMDBP01962
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99418 CYTH2
2
CYTH2 [cytosol]
(R-HSA-8847831)
CYTH2 [Golgi membrane]
(R-HSA-8847829)
0.722
5
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.621
3
UniProt:P53367 ARFP1
0.524
2
UniProt:P60880 SNAP25
7
SNAP25 [plasma membrane]
(R-HSA-2029017)
SNAP25 [tertiary granule membrane]
(R-HSA-6806142)
SNAP25 [specific granule membrane]
(R-HSA-6806154)
SNAP25(199-206) [cytosol]
(R-HSA-5244501)
SNAP25(1-198) [plasma membrane]
(R-HSA-3004550)
SNAP25(198-206) [cytosol]
(R-HSA-5244499)
SNAP25(1-197) [plasma membrane]
(R-HSA-3004546)
0.512
5
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
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