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MLKL [cytosol]
Stable Identifier
R-HSA-5218901
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective RIPK1-mediated regulated necrosis (Homo sapiens)
Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
HCMV UL36 binds MLKL (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
MLKL:UL36 [cytosol] (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
IAV NS1 binds MLKL (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
NS1:MLKL [cytosol] (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
MLKL oligomerizes (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol] (Homo sapiens)
MLKL:ATP [cytosol] (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
NS1:MLKL [cytosol] (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
RIPK3 phosphorylates MLKL (Homo sapiens)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
ATP binds MLKL (Homo sapiens)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol] (Homo sapiens)
MLKL:ATP [cytosol] (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
MLKL binds HSP90:CDC37 (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
MLKL:HSP90:CDC37 [cytosol] (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NB16 MLKL
Gene Names
MLKL
Chain
chain:1-471
Reference Genes
BioGPS Gene:197259 MLKL
COSMIC (genes):MLKL MLKL
CTD Gene:197259 MLKL
dbSNP Gene:197259 MLKL
ENSEMBL:ENSG00000168404 MLKL
HGNC:26617 MLKL
KEGG:hsa:197259 MLKL
Monarch:197259 MLKL
NCBI Gene:197259 MLKL
OMIM:615153 MLKL
UCSC:Q8NB16 MLKL
Reference Transcript
RefSeq:NM_152649.3 MLKL
RefSeq:NM_001142497.2 MLKL
RefSeq:XM_005255834.3 MLKL
Participates
as a component of
MLKL:UL36 [cytosol] (Homo sapiens)
MLKL:HSP90:CDC37 [cytosol] (Homo sapiens)
MLKL:ATP [cytosol] (Homo sapiens)
NS1:MLKL [cytosol] (Homo sapiens)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
as an input of
HCMV UL36 binds MLKL (Homo sapiens)
IAV NS1 binds MLKL (Homo sapiens)
MLKL binds HSP90:CDC37 (Homo sapiens)
RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)
Other forms of this molecule
p-T357,S358-MLKL [cytosol]
K63PolyUb-K50,p-T357,S358-MLKL [cytosol]
Inferred To
MLKL [cytosol]
(Bos taurus)
MLKL [cytosol]
(Dictyostelium discoideum)
MLKL [cytosol]
(Gallus gallus)
MLKL [cytosol]
(Mus musculus)
MLKL [cytosol]
(Sus scrofa)
mlkl [cytosol]
(Xenopus tropicalis)
Mlkl [cytosol]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
2106
OpenTargets
ENSG00000168404
ENSEMBL
ENSP00000303118
,
ENSG00000168404
,
ENSP00000308351
,
ENST00000308807
,
ENST00000306247
HPA
ENSG00000168404-MLKL
GeneCards
MLKL
PRO
Q8NB16
Pharos - Targets
Q8NB16
GlyGen
Q8NB16
HMDB Protein
HMDBP09462
PDB
6ZLE
,
5KNJ
,
7MON
,
6ZVO
,
4M67
,
7JW7
,
7JXU
,
6ZZ1
,
5KO1
,
8SLZ
,
6ZPR
,
6D74
,
4MWI
,
6LK5
,
6BWK
,
6LK6
,
2MSV
,
6O5Z
,
7NM5
,
6UX8
,
7NM4
,
7NM2
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y572 RIPK3
8
RIPK3 [cytosol]
(R-HSA-450328)
p-S199,227-RIPK3 [cytosol]
(R-HSA-5218873)
Ub-K55,363-RIPK3 [cytosol]
(R-HSA-9688825)
RIPK3(1-328) [cytosol]
(R-HSA-9686917)
RIPK3(329-518) [cytosol]
(R-HSA-9686937)
OGlcNAc-T467-RIPK3 [cytosol]
(R-HSA-9687819)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-HSA-9794180)
p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-HSA-9686933)
0.641
10
ChEBI:63770 NECROSULFONAMIDE
0.591
4
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