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p-T357,S358-MLKL [cytosol]
Stable Identifier
R-HSA-5218903
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
MLKL binds PIPs (Homo sapiens)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
MLKL oligomerizes (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
RIPK3 phosphorylates MLKL (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
ITCH polyubiquitinates MLKL at K50 (Homo sapiens)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
MLKL binds FLOT1, FLOT2 (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
MLKL binds IP4, IP5 and IP6 (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
MLKL binds ITCH (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
MLKL binds PDCD6IP and SDCBP (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Stimuli-sensing channels (Homo sapiens)
TRP channels (Homo sapiens)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
TRPV1 transports Ca2+ from extracellular region to cytosol (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
TRPs transport extracellular Ca2+ to cytosol (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-T357,S358-MLKL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NB16 MLKL
Gene Names
MLKL
Chain
chain:1-471
Reference Genes
COSMIC (genes):MLKL MLKL
ENSEMBL:ENSG00000168404 MLKL
HGNC:26617 MLKL
UCSC:Q8NB16 MLKL
Participates
as a repeated unit of
p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
as a component of
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
Other forms of this molecule
K63PolyUb-K50,p-T357,S358-MLKL [cytosol]
MLKL [cytosol]
Inferred To
Ghost homologue of p-T357,S358-MLKL [cytosol]
(Canis familiaris)
phospho-MLKL [cytosol]
(Bos taurus)
phospho-MLKL [cytosol]
(Gallus gallus)
phospho-MLKL [cytosol]
(Sus scrofa)
phospho-mlkl [cytosol]
(Xenopus tropicalis)
phospho-Mlkl [cytosol]
(Mus musculus)
phospho-Mlkl [cytosol]
(Rattus norvegicus)
phospho-p-T357,S358-MLKL [cytosol]
(Dictyostelium discoideum)
Modified Residues
Name
O-phospho-L-serine at 358
Coordinate
358
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 357
Coordinate
357
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
Guide to Pharmacology - Targets
2106
ENSEMBL
ENST00000308807
,
ENSP00000303118
,
ENSP00000308351
,
ENSG00000168404
,
ENST00000306247
OpenTargets
ENSG00000168404
HPA
ENSG00000168404-MLKL
PRO
Q8NB16
Pharos - Targets
Q8NB16
GlyGen
Q8NB16
HMDB Protein
HMDBP09462
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y572 RIPK3
8
RIPK3 [cytosol]
(R-HSA-450328)
p-S199,227-RIPK3 [cytosol]
(R-HSA-5218873)
Ub-K55,363-RIPK3 [cytosol]
(R-HSA-9688825)
RIPK3(1-328) [cytosol]
(R-HSA-9686917)
RIPK3(329-518) [cytosol]
(R-HSA-9686937)
OGlcNAc-T467-RIPK3 [cytosol]
(R-HSA-9687819)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-HSA-9794180)
p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-HSA-9686933)
0.641
10
ChEBI:63770 NECROSULFONAMIDE
0.591
4
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