Reactome | p-T357,S358-MLKL [cytosol]

p-T357,S358-MLKL [cytosol]

Stable Identifier

R-HSA-5218903

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Regulated Necrosis (Homo sapiens)
  - RIPK1-mediated regulated necrosis (Homo sapiens)
    - MLKL binds PIPs (Homo sapiens)
      - RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
    - MLKL oligomerizes (Homo sapiens)
      - (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Homo sapiens)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
    - RIPK3 phosphorylates MLKL (Homo sapiens)
      - (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
    - Regulation of necroptotic cell death (Homo sapiens)
      - MLKL binds FLOT1, FLOT2 (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
      - MLKL binds IP4, IP5 and IP6 (Homo sapiens)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Homo sapiens)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
      - MLKL binds PDCD6IP and SDCBP (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-T357,S358-MLKL [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NB16 MLKL

Gene Names

MLKL

Chain

chain:1-471

Reference Genes

BioGPS Gene:197259 MLKL

COSMIC (genes):MLKL MLKL

CTD Gene:197259 MLKL

dbSNP Gene:197259 MLKL

ENSEMBL:ENSG00000168404.13 MLKL

HGNC:26617 MLKL

KEGG Gene (Homo sapiens):197259 MLKL

Monarch:197259 MLKL

NCBI Gene:197259 MLKL

OMIM:615153 MLKL

UCSC:Q8NB16 MLKL

Reference Transcript

Other Identifiers

11754630_a_at

16828344

197259

238025_PM_at

238025_at

3699083

3699086

3699087

3699090

3699091

3699093

3699104

3699105

3699107

3699108

3699110

3699111

3699114

3699119

3699120

3699121

3699125

3699126

3699127

3699128

3699129

50829_at

8002778

A_23_P61050

A_24_P185044

GE87884

GO:0000166

GO:0003674

GO:0004672

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006468

GO:0007166

GO:0008150

GO:0012501

GO:0016020

GO:0016301

GO:0019899

GO:0019901

GO:0023052

GO:0030054

GO:0036211

GO:0042802

GO:0043167

GO:0043226

GO:0044877

GO:0051607

GO:0065003

GO:0070207

GO:0070266

GO:0097527

GO:0097528

GO:0098542

HMNXSV003013902

HMNXSV003026069

Hs.119878.0.A1_3p_at

ILMN_1667825

ILMN_1715863

ILMN_1737498

TC16001270.hg

Participates

as a repeated unit of

p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)

as a component of

(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)

Other forms of this molecule

MLKL [cytosol]

Inferred To

phospho-MLKL [cytosol] (Bos taurus)

phospho-MLKL [cytosol] (Sus scrofa)

phospho-Mlkl [cytosol] (Rattus norvegicus)

phospho-p-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)

phospho-p-T357,S358-MLKL [cytosol] (Mus musculus)

Modified Residues

Name

O-phospho-L-serine at 358

Coordinate

358

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 357

Coordinate

357

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_005255891.1, NP_001135969.1, NP_689862.1

Guide to Pharmacology - Targets

2106

OpenTargets

ENSG00000168404

GeneCards

Q8NB16

HPA

ENSG00000168404-MLKL

Ensembl

ENST00000308807, ENSP00000308351, ENSG00000168404, ENSP00000303118, ENST00000306247

PRO

Q8NB16

Pharos - Targets

Q8NB16

HMDB Protein

HMDBP09462

PDB

4M67, 7NM2, 2MSV, 5KNJ, 6ZLE, 6UX8, 6BWK, 4MWI, 7MON, 6O5Z, 7NM5, 7NM4, 5KO1, 6ZPR, 6LK5, 7JW7, 6ZZ1, 7JXU, 6LK6, 6D74, 6ZVO

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y572 RIPK3	7	p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) RIPK3(329-518) [cytosol] (R-HSA-9686937) RIPK3 [cytosol] (R-HSA-450328) p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825) RIPK3(1-328) [cytosol] (R-HSA-9686917)	0.641	10
ChEBI:63770 NECROSULFONAMIDE			0.591	4

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