HCMV UL36 binds MLKL

Stable Identifier
R-HSA-9698677
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
cytosol
ReviewStatus
5/5
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HCMV UL36 binds MLKL
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Human cytomegalovirus (HCMV) protein pUL36 was found to bind mixed lineage kinase domain-like protein (MLKL) and target MLKL for degradation in HCMV-infected TERT-immortalized primary human fetal foreskin fibroblasts (HFFF-TERTs) (Fletcher-Etherington A et al. 2020). Furthermore, mutation of pUL36 Cys131 abrogated MLKL degradation and restored necroptosis in HFFF-TERTs. The same residue was also required for pUL36-mediated inhibition of apoptosis by preventing proteolytic activation of procaspase-8, suggesting that pUL36 acts as a multifunctional inhibitor of both apoptotic and necroptotic cell death (Fletcher-Etherington A et al. 2020; Skaletskaya A et al. 2001).
Literature References
PubMed ID Title Journal Year
32690704 Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor

Stanton, RJ, Nightingale, K, Davison, AJ, Nichols, J, Nobre, L, Weekes, MP, Antrobus, R, Fletcher-Etherington, A

Proc. Natl. Acad. Sci. U.S.A. 2020
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
modulation by virus of host cellular process (0019054)
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Authored
Shamovsky, V  (2020-05-21)
Reviewed
Murphy, JM  (2020-08-28)
Created
Shamovsky, V  (2020-08-28)
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