HCMV UL36 binds MLKL

Stable Identifier
R-HSA-9698677
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
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Human cytomegalovirus (HCMV) protein pUL36 was found to bind mixed lineage kinase domain-like protein (MLKL) and target MLKL for degradation in HCMV-infected TERT-immortalized primary human fetal foreskin fibroblasts (HFFF-TERTs) (Fletcher-Etherington A et al. 2020). Furthermore, mutation of pUL36 Cys131 abrogated MLKL degradation and restored necroptosis in HFFF-TERTs. The same residue was also required for pUL36-mediated inhibition of apoptosis by preventing proteolytic activation of procaspase-8, suggesting that pUL36 acts as a multifunctional inhibitor of both apoptotic and necroptotic cell death (Fletcher-Etherington A et al. 2020; Skaletskaya A et al. 2001).

Literature References
PubMed ID Title Journal Year
32690704 Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor

Fletcher-Etherington, A, Nobre, L, Nightingale, K, Antrobus, R, Nichols, J, Davison, AJ, Stanton, RJ, Weekes, MP

Proc. Natl. Acad. Sci. U.S.A. 2020
Participants
Participates
Event Information
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Authored
Reviewed
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