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(RIPK1:RIPK3)oligomer:3xMLKL
Stable Identifier
R-HSA-5218909
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)
(RIPK1:RIPK3)oligomer:3xMLKL [cytosol] (Homo sapiens)
RIPK3 phosphorylates MLKL (Homo sapiens)
(RIPK1:RIPK3)oligomer:3xMLKL [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
22265413
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
Cell
2012
Participants
components
3 x
MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
Participant Of
input
RIPK3 phosphorylates MLKL
output
RIPK1:RIPK3 oligomer binds MLKL
Inferred To
(RIPK1:RIPK3)oligomer:3xMLKL [cytosol] (Bos taurus)
(RIPK1:RIPK3)oligomer:3xMLKL [cytosol] (Mus musculus)
(RIPK1:RIPK3)oligomer:3xMLKL [cytosol] (Rattus norvegicus)
(RIPK1:RIPK3)oligomer:3xMLKL [cytosol] (Sus scrofa)
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