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IAV NS1 binds MLKL
Stable Identifier
R-HSA-9686343
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective RIPK1-mediated regulated necrosis (Homo sapiens)
Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
IAV NS1 binds MLKL (Homo sapiens)
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Co-immunoprecipitation assays in influenza A virus (IAV)-infected human leukemia monocytic THP1 cell, as well as NS1-transfected human embryonic kidney (HEK293) cells showed that viral NS1 interacts with mixed-lineage kinase domain-like protein (MLKL) in an RNA-dependent manner (Gaba A et al. 2019). The second brace helix of MLKL is responsible for interacting with NS1 (Gaba A et al. 2019). The interaction of NS1 with MLKL is thought to increased MLKL membrane translocation. Moreover, the MLKL:NS1 interaction enhanced NLRP3 inflammasome activation and increases IL-1β processing and secretion (Gaba A et al. 2019).
Literature References
PubMed ID
Title
Journal
Year
30355688
The NS1 Protein of Influenza A Virus Participates in Necroptosis by Interacting with MLKL and Increasing Its Oligomerization and Membrane Translocation
Zhou, Y
,
Liu, G
,
Lu, Y
,
Park, HS
,
Xu, F
,
Gaba, A
J. Virol.
2019
Participants
Input
MLKL [cytosol]
(Homo sapiens)
NS1 dimer [cytosol]
(Influenza A virus)
Output
NS1:MLKL [cytosol]
(Homo sapiens)
Participates
as an event of
Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Shamovsky, V (2020-05-21)
Reviewed
Murphy, JM (2020-08-28)
D'Eustachio, P (2020-06-26)
Created
Shamovsky, V (2020-04-30)
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