Reactome | RIPK3 [cytosol]

RIPK3 [cytosol]

Stable Identifier

R-HSA-450328

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RIP3

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective RIPK1-mediated regulated necrosis (Homo sapiens)
    - Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
      - HSV1 RIR1 binds RIPK3 (Homo sapiens)
        
        HSV1 RIR1:RIPK3 [cytosol] (Homo sapiens)
        
        RIPK3 [cytosol] (Homo sapiens)
        
        RIPK3 [cytosol] (Homo sapiens)
- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        SARS-CoV-1-host interactions (Homo sapiens)
        
        SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
        
        SARS-CoV-1 3a tetramerizes (Homo sapiens)
        
        RIPK3:O-glycosyl 3a [plasma membrane] (Homo sapiens)
        
        RIPK3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y572 RIPK3

Gene Names

RIPK3, RIP3

Chain

chain:1-518

Reference Genes

BioGPS Gene:11035 RIPK3

COSMIC (genes):RIPK3 RIPK3

CTD Gene:11035 RIPK3

dbSNP Gene:11035 RIPK3

ENSEMBL:ENSG00000129465 RIPK3

HGNC:10021 RIPK3

KEGG:hsa:11035 RIPK3

Monarch:11035 RIPK3

NCBI Gene:11035 RIPK3

OMIM:605817 RIPK3

UCSC:Q9Y572 RIPK3

Reference Transcript

RefSeq:NM_006871.3 RIPK3

Other Identifiers

11035

11723020_a_at

11747951_a_at

11751012_a_at

11761088_at

16791371

228139_PM_at

228139_at

3558227

3558228

3558229

3558230

3558232

3558233

3558234

3558235

3558236

3558237

3558238

3558239

3558240

3558241

3558242

3558243

3558244

3558245

3558246

3558247

3558248

3558249

3558250

3558251

3558252

3558253

3558254

3558255

3558257

54622_at

7978312

A_23_P14559

A_33_P3303291

GE62641

GO:0001914

GO:0002376

GO:0002819

GO:0003713

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006355

GO:0006468

GO:0006915

GO:0007165

GO:0012501

GO:0016740

GO:0030154

GO:0032147

GO:0032649

GO:0032991

GO:0033077

GO:0036211

GO:0038061

GO:0042802

GO:0042981

GO:0043029

GO:0043226

GO:0044877

GO:0045893

GO:0046006

GO:0048535

GO:0048536

GO:0048538

GO:0048856

GO:0051092

GO:0051607

GO:0060090

GO:0060545

GO:0070235

GO:0070266

GO:0070301

GO:0072593

GO:0097190

GO:0097300

GO:0097527

GO:0097528

GO:0098542

GO:0106310

GO:0140096

GO:0140110

GO:1990000

GO:2000377

GO:2000379

GO:2000452

GO:2001244

HMNXSV003056618

Hs.268551.0.S1_3p_at

ILMN_1763763

PH_hs_0013735

TC14002317.hg

Participates

as a component of

as an input of

This entity regulates

Negatively

Other forms of this molecule

p-S199,227-RIPK3 [cytosol]

Ub-K55,363-RIPK3 [cytosol]

RIPK3(1-328) [cytosol]

RIPK3(329-518) [cytosol]

OGlcNAc-T467-RIPK3 [cytosol]

K33polyUb-K197,302,364-RIPK3 [cytosol]

p-S199,227, K48pUb-363-RIPK3 [cytosol]

Inferred To

Ghost homologue of RIPK3 [cytosol] (Danio rerio)

Ghost homologue of RIPK3 [cytosol] (Drosophila melanogaster)

Ghost homologue of RIPK3 [cytosol] (Gallus gallus)

Homologues of RIPK3 [cytosol] (Dictyostelium discoideum)

RIPK3 [cytosol] (Bos taurus)

RIPK3 [cytosol] (Canis familiaris)

RIPK3 [cytosol] (Dictyostelium discoideum)

RIPK3 [cytosol] (Mus musculus)

RIPK3 [cytosol] (Rattus norvegicus)

RIPK3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_006862.2

Guide to Pharmacology - Targets

2191

OpenTargets

ENSG00000129465

ENSEMBL

ENSP00000216274, ENST00000643393, ENSP00000452328, ENST00000554756, ENST00000646516, ENSP00000495490, ENST00000216274, ENSP00000495915

ZINC - Substances

RIPK3_HUMAN

ZINC target

Q9Y572

PRO

Q9Y572

GlyGen

Q9Y572

PDB

7MX3, 5V7Z, 7MON, 5ZCK, 7DAC, 7DA4

IntEnz

2.7.11.1

HPA

ENSG00000129465-RIPK3

Pharos - Targets

Q9Y572

HMDB Protein

HMDBP01148

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13546 RIPK1	20	RIPK1 [cytosol] (R-HSA-168651) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) p-S166-RIPK1 [cytosol] (R-HSA-5218872) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S320-RIPK1 [cytosol] (R-HSA-9815498) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1(1-324) [cytosol] (R-HSA-5212664) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324N [cytosol] (R-HSA-9693930) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308)	0.972	27
UniProt:Q9Y572 RIPK3	8	RIPK3 [cytosol] (R-HSA-450328) p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825) RIPK3(1-328) [cytosol] (R-HSA-9686917) RIPK3(329-518) [cytosol] (R-HSA-9686937) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) K33polyUb-K197,302,364-RIPK3 [cytosol] (R-HSA-9794180) p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933)	0.728	6
UniProt:Q8NB16 MLKL	3	K63PolyUb-K50,p-T357,S358-MLKL [cytosol] (R-HSA-9793468) p-T357,S358-MLKL [cytosol] (R-HSA-5218903) MLKL [cytosol] (R-HSA-5218901)	0.641	10
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.602	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.602	3
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.564	2
UniProt:J9TC74 J9TC74			0.463	3
UniProt:Q96HS1 PGAM5			0.462	3

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