PKC phosphorylates sphingosine kinase 1

Stable Identifier
Reaction [transition]
Homo sapiens
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VEGF mediated activation of ERK1/2 depends on the activity of PKC. Sphingosine kinase 1 (SPHK1) has been identified as the connecting link between PKC and Ras activation. Activated SPHK1 does not activate Ras-GEF directly but rather modulates Ras-GAP activity to favour Ras activation. VEGF-mediated stimulation of SPHK1 results from the direct phosphorylation of SPHK1 by PKC (Shu et al. 2002). S225 in SPHK1 may be the target site of phosphorylation (Piston et al. 2003).

Literature References
PubMed ID Title Journal Year
12391145 Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases

Wu, W, Mosteller, RD, Shu, X, Broek, D

Mol. Cell. Biol. 2002
14532121 Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

Pitson, SM, Lynn, HE, Vadas, MA, Wattenberg, BW, Moretti, PA, Zebol, JR, Xia, P

EMBO J. 2003
Catalyst Activity

protein kinase C activity of DAG:active PKC:Ca+2 [plasma membrane]

Orthologous Events
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