p-S225-SPHK1 localizes to cytosol

Stable Identifier
R-HSA-9836621
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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p-S225-SPHK1 localizes to cytosol
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Activated sphingosin kinase 1 (SPHK1) gets exported from nucleus. This process is part of a feedback loop between PKR and SPHK1, activating pro-survival pathways in the cellular response to external stimuli (Qiao et al, 2020).
Literature References
PubMed ID Title Journal Year
32801355 Cell fate determined by the activation balance between PKR and SPHK1

Deng, Y, Jiang, T, Chen, X, Wen, X, Tang, S, Qiao, H, Mu, P, Hu, Z, Wen, J

Cell Death Differ 2021
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Orthologous Events
p-S225-SPHK1 localizes to cytosol (Bos taurus)
p-S225-SPHK1 localizes to cytosol (Caenorhabditis elegans)
p-S225-SPHK1 localizes to cytosol (Canis familiaris)
p-S225-SPHK1 localizes to cytosol (Dictyostelium discoideum)
p-S225-SPHK1 localizes to cytosol (Drosophila melanogaster)
p-S225-SPHK1 localizes to cytosol (Gallus gallus)
p-S225-SPHK1 localizes to cytosol (Mus musculus)
p-S225-SPHK1 localizes to cytosol (Rattus norvegicus)
p-S225-SPHK1 localizes to cytosol (Saccharomyces cerevisiae)
p-S225-SPHK1 localizes to cytosol (Schizosaccharomyces pombe)
p-S225-SPHK1 localizes to cytosol (Sus scrofa)
Authored
Stephan, R  (2023-05-31)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-31)
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