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p-S225-SPHK1 localizes to cytosol
Stable Identifier
R-HSA-9836621
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-S225-SPHK1 localizes to cytosol (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated sphingosin kinase 1 (SPHK1) gets exported from nucleus. This process is part of a feedback loop between PKR and SPHK1, activating pro-survival pathways in the cellular response to external stimuli (Qiao et al, 2020).
Literature References
PubMed ID
Title
Journal
Year
32801355
Cell fate determined by the activation balance between PKR and SPHK1
Deng, Y
,
Jiang, T
,
Chen, X
,
Wen, X
,
Tang, S
,
Qiao, H
,
Mu, P
,
Hu, Z
,
Wen, J
Cell Death Differ
2021
Participants
Input
p-S225-SPHK1 [nucleoplasm]
(Homo sapiens)
Output
p-S225-SPHK1 [cytosol]
(Homo sapiens)
Participates
as an event of
PKR-mediated signaling (Homo sapiens)
Orthologous Events
p-S225-SPHK1 localizes to cytosol (Bos taurus)
p-S225-SPHK1 localizes to cytosol (Caenorhabditis elegans)
p-S225-SPHK1 localizes to cytosol (Canis familiaris)
p-S225-SPHK1 localizes to cytosol (Dictyostelium discoideum)
p-S225-SPHK1 localizes to cytosol (Drosophila melanogaster)
p-S225-SPHK1 localizes to cytosol (Gallus gallus)
p-S225-SPHK1 localizes to cytosol (Mus musculus)
p-S225-SPHK1 localizes to cytosol (Rattus norvegicus)
p-S225-SPHK1 localizes to cytosol (Saccharomyces cerevisiae)
p-S225-SPHK1 localizes to cytosol (Schizosaccharomyces pombe)
p-S225-SPHK1 localizes to cytosol (Sus scrofa)
Authored
Stephan, R (2023-05-31)
Reviewed
Patel, RC (2023-08-16)
Created
Stephan, R (2023-05-31)
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