SPHK1 binds PKR

Stable Identifier
R-HSA-9836606
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SPHK1 binds PKR
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Sphingosine kinase 1 (SPHK1) that has been phosphorylated at S225 binds to inactive protein kinase R (PKR, EIF2AK2), preventing its activation, antagonizing the apoptotic pathways (Qiao et al, 2020).
Literature References
PubMed ID Title Journal Year
32801355 Cell fate determined by the activation balance between PKR and SPHK1

Qiao, H, Jiang, T, Mu, P, Chen, X, Wen, X, Hu, Z, Tang, S, Wen, J, Deng, Y

Cell Death Differ 2021
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Orthologous Events
SPHK1 binds PKR (Bos taurus)
SPHK1 binds PKR (Caenorhabditis elegans)
SPHK1 binds PKR (Canis familiaris)
SPHK1 binds PKR (Dictyostelium discoideum)
SPHK1 binds PKR (Drosophila melanogaster)
SPHK1 binds PKR (Gallus gallus)
SPHK1 binds PKR (Mus musculus)
SPHK1 binds PKR (Rattus norvegicus)
SPHK1 binds PKR (Sus scrofa)
SPHK1 binds PKR (Xenopus tropicalis)
Authored
Stephan, R  (2023-05-30)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-31)
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