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G76-NEDD8-C116-AcM-UBE2F [cytosol]
Stable Identifier
R-HSA-8951758
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F [cytosol] (Homo sapiens)
G76-NEDD8-C116-AcM-UBE2F [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F [cytosol] (Homo sapiens)
G76-NEDD8-C116-AcM-UBE2F [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F [cytosol] (Homo sapiens)
G76-NEDD8-C116-AcM-UBE2F [cytosol] (Homo sapiens)
Transfer of NEDD8 to AcM-UBE2F (Homo sapiens)
NEDD8-AcM-UBE2F [cytosol] (Homo sapiens)
G76-NEDD8-C116-AcM-UBE2F [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969M7 UBE2F
Gene Names
UBE2F, NCE2
Chain
chain:1-185
Reference Genes
BioGPS Gene:140739 UBE2F
COSMIC (genes):UBE2F UBE2F
CTD Gene:140739 UBE2F
dbSNP Gene:140739 UBE2F
ENSEMBL:ENSG00000184182 UBE2F
ENSEMBL_homo_sapiens_GENE:ENSG00000184182.19 UBE2F
HGNC:12480 UBE2F
KEGG Gene (Homo sapiens):140739 UBE2F
Monarch:140739 UBE2F
NCBI Gene:140739 UBE2F
OMIM:617700 UBE2F
UCSC:Q969M7 UBE2F
Reference Transcript
RefSeq:NM_001278305.1 UBE2F
RefSeq:NM_001278308.1 UBE2F
RefSeq:NM_080678.2 UBE2F
RefSeq:NM_001278306.1 UBE2F
RefSeq:NM_001278307.1 UBE2F
Other Identifiers
11739398_a_at
11739399_s_at
11754037_x_at
11756751_x_at
11757677_x_at
11763178_at
11763179_s_at
11763180_x_at
140739
225783_PM_at
225783_at
225787_PM_at
225787_at
225791_PM_at
225791_at
231948_PM_s_at
231948_s_at
2534566
2534567
2534573
2534577
2534579
2534586
2534589
2534592
2534596
2534602
2534603
2534604
3895421
49056_at
49057_g_at
57184_at
8049574
A_14_P111866
A_14_P121935
GE78959
GE87718
GO:0000166
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005829
GO:0016740
GO:0019787
GO:0019788
GO:0032446
GO:0036211
GO:0043226
GO:0043687
GO:0045116
GO:0061654
GO:0061663
GO:0140096
HMNXSV003008100
Hs.289051.0.A1_3p_a_at
Hs.289051.0.A1_3p_x_at
Hs.289051.0.A2_3p_at
Hs.289051.0.A3_3p_at
Hs.289051.1.S1_3p_a_at
ILMN_2164242
PH_hs_0022726
TC02005014.hg
Participates
as a component of
NEDD8-AcM-UBE2F [cytosol] (Homo sapiens)
Other forms of this molecule
AcM-UBE2F [cytosol]
UBE2F [cytosol]
Inferred To
ubc12 [cytosol]
(Schizosaccharomyces pombe)
ube2m [cytosol]
(Dictyostelium discoideum)
UBE2F [cytosol]
(Bos taurus)
UBE2F [cytosol]
(Canis familiaris)
UBE2F [cytosol]
(Gallus gallus)
Ube2f [cytosol]
(Mus musculus)
Ube2f [cytosol]
(Rattus norvegicus)
G76-NEDD8-C116-AcM-UBE2F [cytosol]
(Plasmodium falciparum)
UBC12 [cytosol]
(Saccharomyces cerevisiae)
ube2f [cytosol]
(Danio rerio)
Ghost homologue of G76-NEDD8-C116-AcM-UBE2F [cytosol]
(Caenorhabditis elegans)
Ghost homologue of G76-NEDD8-C116-AcM-UBE2F [cytosol]
(Drosophila melanogaster)
Ghost homologue of G76-NEDD8-C116-AcM-UBE2F [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
N-acetyl-L-methionine at 1
Coordinate
1
PsiMod Name
N-acetyl-L-methionine [MOD:00058]
PsiMod Definition
A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine.
Name
Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 116 and 76
Coordinate
116
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_001265237.1
,
NP_001265234.1
,
NP_001265236.1
,
NP_542409.1
,
NP_001265235.1
OpenTargets
ENSG00000184182
GeneCards
Q969M7
HPA
ENSG00000184182-UBE2F
Ensembl
ENSP00000409749
,
ENST00000409953
,
ENSP00000386680
,
ENST00000272930
,
ENSG00000184182
,
ENST00000409633
,
ENST00000612130
,
ENSP00000478474
,
ENSP00000272930
,
ENSP00000387299
,
ENST00000441728
,
ENST00000433241
,
ENSP00000393515
,
ENST00000414443
,
ENSP00000399183
PRO
Q969M7
Pharos - Targets
Q969M7
PDB
4GBA
,
3FN1
,
2EDI
HMDB Protein
HMDBP09265
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26367 PAX6
1
PAX6 [nucleoplasm]
(R-HSA-3009044)
0.556
3
UniProt:P62879 GNB2
4
GNB2 [cytosol]
(R-HSA-6814421)
Partially folded GNB2 [cytosol]
(R-HSA-8850536)
Unfolded GNB2 [cytosol]
(R-HSA-6814202)
GNB2 [plasma membrane]
(R-HSA-164335)
0.556
3
UniProt:P80188 LCN2
2
LCN2 [specific granule lumen]
(R-HSA-6799614)
LCN2 [extracellular region]
(R-HSA-5215934)
0.556
3
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