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NEIL2 [nucleoplasm]
Stable Identifier
R-HSA-5649650
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Endonuclease 8-like 2, DNA glycosylase/AP lyase Neil2, NEH2
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
NEIL2 cleaves 5-OHU from damaged DNA (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2:5-OHU-dsDNA [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
NEIL2 recognizes and binds 5-OHU-dsDNA (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2:5-OHU-dsDNA [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 incises DNA strand 5' to the AP site (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 recruits POLB to incised AP site (Homo sapiens)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Homo sapiens)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969S2 NEIL2
Gene Names
NEIL2
Chain
initiator methionine:, chain:2-332
Reference Genes
BioGPS Gene:252969 NEIL2
COSMIC (genes):NEIL2 NEIL2
CTD Gene:252969 NEIL2
dbSNP Gene:252969 NEIL2
ENSEMBL:ENSG00000154328 NEIL2
HGNC:18956 NEIL2
Monarch:252969 NEIL2
NCBI Gene:252969 NEIL2
OMIM:608933 NEIL2
UCSC:Q969S2 NEIL2
Reference Transcript
RefSeq:NM_001135747.1 NEIL2
RefSeq:XM_005272382.2 NEIL2
RefSeq:NM_145043.2 NEIL2
RefSeq:XM_005272383.2 NEIL2
RefSeq:NM_001135748.1 NEIL2
RefSeq:NM_001135746.1 NEIL2
RefSeq:XM_017013301.1 NEIL2
Other Identifiers
11723394_s_at
11742118_a_at
17065798
226585_PM_at
226585_at
252969
3086184
3086185
3086186
3086187
3086188
3086191
3086192
3086193
3086195
3086196
3086197
3086198
3086199
45665_at
8144658
GE540628
GO:0003676
GO:0003677
GO:0003684
GO:0003824
GO:0003906
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005856
GO:0006281
GO:0006284
GO:0008017
GO:0008092
GO:0008270
GO:0015630
GO:0016787
GO:0016798
GO:0016799
GO:0016829
GO:0019104
GO:0043226
GO:0043231
GO:0045008
GO:0046872
GO:0055086
GO:0072686
GO:0140078
GO:0140097
GO:1901135
HMNXSV003000390
Hs.293818.0.A1_3p_at
ILMN_1715680
PH_hs_0015268
TC08000091.hg
Participates
as a candidate of
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
as an input of
NEIL2 recognizes and binds 5-OHU-dsDNA (Homo sapiens)
as a component of
NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL2:5-OHU-dsDNA [nucleoplasm] (Homo sapiens)
Inferred To
NEIL2 [nucleoplasm]
(Bos taurus)
NEIL2 [nucleoplasm]
(Canis familiaris)
NEIL2 [nucleoplasm]
(Gallus gallus)
NEIL2 [nucleoplasm]
(Mus musculus)
NEIL2 [nucleoplasm]
(Sus scrofa)
neil2 [nucleoplasm]
(Xenopus tropicalis)
Neil2 [nucleoplasm]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000154328
ENSEMBL
ENSP00000435657
,
ENSP00000394023
,
ENST00000710795
,
ENST00000710794
,
ENSP00000284503
,
ENST00000710793
,
ENST00000528323
,
ENST00000710792
,
ENST00000436750
,
ENST00000284503
,
ENST00000403422
,
ENST00000455213
,
ENSP00000518488
,
ENSP00000518489
,
ENSP00000518491
,
ENSP00000384070
,
ENST00000710791
,
ENSP00000518492
,
ENSP00000518490
,
ENSP00000397538
IntEnz
4.2.99.18
HPA
ENSG00000154328-NEIL2
PRO
Q969S2
Pharos - Targets
Q969S2
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.718
6
UniProt:P50221 MEOX1
0.718
6
UniProt:O43186 CRX
0.556
3
UniProt:P80188 LCN2
2
LCN2 [extracellular region]
(R-HSA-5215934)
LCN2 [specific granule lumen]
(R-HSA-6799614)
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q6ZTQ4 CDHR3
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:Q02548 PAX5
1
PAX5 [nucleoplasm]
(R-HSA-158583)
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
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