Reactome | UBA2-G92-SUMO3 [nucleoplasm]

UBA2-G92-SUMO3 [nucleoplasm]

Stable Identifier

R-HSA-3730627

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Small ubiquitin-related modifier 3, SUMO3_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
12383504	Molecular features of human ubiquitin-like SUMO genes and their encoded proteins Su, HL, Li, SS	Gene	2002

External Reference Information

External Reference

UniProt:P55854 SUMO3

Gene Names

SUMO3, SMT3A, SMT3H1

Chain

chain:1-92, propeptide:93-103

Reference Genes

BioGPS Gene:6612 SUMO3

COSMIC (genes):SUMO3 SUMO3

CTD Gene:6612 SUMO3

dbSNP Gene:6612 SUMO3

ENSEMBL:ENSG00000184900 SUMO3

ENSEMBL_homo_sapiens_GENE:ENSG00000184900.16 SUMO3

HGNC:11124 SUMO3

KEGG Gene (Homo sapiens):6612 SUMO3

Monarch:6612 SUMO3

NCBI Gene:6612 SUMO3

OMIM:602231 SUMO3

UCSC:P55854 SUMO3

Reference Transcript

Other Identifiers

11721797_at

11721798_a_at

11764238_at

16926433

200739_PM_s_at

200739_s_at

200740_PM_s_at

200740_s_at

38738_at

3934670

3934671

3934672

3934673

3934674

3934678

3934685

3934686

3934688

6612

8070811

A_23_P102937

A_24_P245767

GE60218

GO:0000776

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0016605

GO:0016925

GO:0031386

GO:0036211

GO:0043226

GO:0043392

GO:0044389

GO:1900180

HMNXSV003052673

Hs.85119.0.A1_3p_a_at

ILMN_1725642

PH_hs_0004814

PH_hs_0031377

TC21000536.hg

X99584_at

g5902095_3p_a_at

Participates

as a component of

SUMO3:UBA2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

SUMO3(1-103) [nucleoplasm]

lysyl-G92-SUMOyl-K11-SUMO3 [nucleoplasm]

SUMO3 [nucleoplasm]

UBE2I-G92-SUMO3 [nucleoplasm]

Modified Residues

Name

Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 92 and 173

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_001273345.1, NP_008867.2

OpenTargets

ENSG00000184900

GeneCards

P55854

HPA

ENSG00000184900-SUMO3

Ensembl

ENSP00000330343, ENSP00000409666, ENSG00000184900, ENST00000411651, ENST00000332859

PRO

P55854

Pharos - Targets

P55854

PDB

2MP2, 7ZJU, 6NNQ, 6K5R, 2IO1, 7R2E, 1U4A

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HC62 SENP2	1	SENP2 [nucleoplasm] (R-HSA-2984298)	0.799	7
UniProt:Q5W0Q7 USPL1			0.782	17
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.669	3
UniProt:Q6PEW1 ZCH12			0.666	4
UniProt:Q99700-5 Q997005			0.556	3
UniProt:A4D161 F221A			0.556	3
UniProt:O15060 ZBT39			0.556	3
UniProt:Q86T24 KAISO			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q96IT1 ZNF496	1	ZNF496 [nucleoplasm] (R-HSA-1247860)	0.556	3
UniProt:P54253 ATX1			0.556	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:P62990 UBIQ			0.544	2
UniProt:P23497 SP100	3	polySUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) monoSUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SP100 [nucleoplasm] (R-HSA-1031705)	0.524	2
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.499	2
UniProt:Q86X55 CARM1	1	CARM1 [nucleoplasm] (R-HSA-400139)	0.499	2
UniProt:P11474 ESRRA	1	ESRRA [nucleoplasm] (R-HSA-446159)	0.463	2